Bayer Technology Services Gmbh

Bayer Intellectual Property Gmbh

Eginhard Schick

Michael Pawlak

Markus Ehrat

Gert Ludwig Duveneck

Eveline Schürmann-Mader

Martin Andreas Bopp

Andreas Peter Abel

Gerhard Matthias Kresbach

Nania Graciela Schärer-Hernández

Peter Oroszlan

Dominic Utinger

Claudio Calonder

Miro Venturi

The invention relates to several embodiments of equipment for coating substrates for detecting one or more analytes by way of an affinity assay method, comprising: a receptacle receiving a liquid to be atomized ('liquid receptacle') with substances (compounds) to be deposited onto at least one surface of said substrates and an atomized volume produced by the liquid in the operating state; an actuator for triggering the atomization process and; a fixture for receiving and storing the substrates during the coating process. The invention is characterized in that the substrates are not in contact with the surface of the liquid to be atomized. The invention also relates to several embodiments of methods for coating substrates with coupler and/or passivation layers for use in the detection of one or more analytes by way of an affinity assay method.

Apparatus and method for coating substrates for analyte detection by means of an affinity assay method

A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to the (geometrical) arrangement of the sample compartments, combined with the base plate. The arrangement allows for supplying to or removing from the sample compartments, which can be arranged at a high quantity on a small base area, even very small amounts of samples or reagents. An arrangement of one or more sample compartments includes a base plate and a body combined with the base plate in such a way that one or more recesses for generation of one or more flow cells fluidically sealed against one another, each with at least one inlet and one outlet, are formed between the base plate and the body, wherein at least one outlet of each flow cell is joined with a reservoir fluidically connected with the flow cell, the reservoir being operable to receive liquid exiting the flow cell, besides methods for its manufacturing and their use.

Flow cell array and the utilization thereof for multianalyte determination

The present invention relates to a process for detecting one or more analytes in one or more samples of biological origin having complex composition. The present invention also relates to a microarray for quantitative determination of one or more analytes in samples of biological origin having complex composition which are immobilized in measurement ranges of microarray, and also to a quantitative detection method based thereon.

Process for determining one or more analytes in samples of biological origin having complex composition, and use thereof

The invention is related to different embodiments of a kit for the simultaneous qualitative and/or quantitative determination of a multitude of analytes comprising

Kit and method for multi-analyte determination

Kit and method for determining a plurality of analytes

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Rheinfelden, Germany

Eginhard Schick