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Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr

Institut Organicheskogo Sinteza an Latvii

Uralsky Politekhnichesky Institut

Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi

Radiatsionnoi Gigieny

Institut Organischeskogo Sinteza Leningradsky Nauchno-issledovatelsky

Egils A Biseniex

Gunar Y Dubur

Yan R Uldrikis

Agris A Kimenis

Maris M Veveris

Evgeny V Ivanov

Aina A Zidermane

Ieva E Preisa

Natalia V Barmenkova

Vitaly G Platonov

Yanis J Polis

Jury O Yakubovsky-Lipsky

Vasily G Baklykov

Tatyana V Ponomareva

Natalya V Makarova

Oleg U Kiselev

Oleg N Chupakhin

Gennady N Merkushev

Valentina M Guseva

Galina M Petrova

Mikhail G Ponizovsky

Valery N Charushin

Vera I Ilienko

Gunar D Tirzit

Bornyl and isobornyl esters of carboxylic acids of condensed

Novel compounds, that is, alkoxy- and phenoxy-alkyl esters of 2,6-dimethyl-4-(2-difluoromethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxy li c acid have the following general formula useful for producing hypotensive and vasodilation effects. ##STR1##

Alkoxy-and phenoxy alkyl esters of

A preparation for prevention and treatment of radiation burning lesions of the skin comprising an active principle, viz. 2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine of the following formula: ##STR1## and a pharmaceutically acceptable diluent.

Preparation for preventing and treatment of skin radiation burn lesions

A compound 2,6-dimethyl-3,5-bis-(1-adamantylhydroxycarbonyl)-4-(2-difluoromethoxyphen yl)-1,4-dihydropyridine of the formula ##STR1## is proposed. Said compound possesses antianginal activity.

2,6-Dimethyl-3,5-bis-(1-adamantylhydr

2-(2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine-4-carboxamide) glutaric acid of formula I and its disodium salt of formula II ##STR1## Said acid is obtained from glutaminic acid and dimethyl 3,5-diethoxycarbonyl-1,4-dihydroisonicotic acid. For obtaining disodium salt, said acid is reacted with a caustic soda solution. These compounds possess antiarrhythmic activity.

2-(2,6-Dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine-4-carboxamide

2,6-Dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid esters of the general formula: ##STR1## wherein R is a substituted alkyl or terpenyl. A method for preparing said esters comprises reacting esters of acetoacetic acid of the general formula: CH.sub.3 COCH.sub.2 COOR, wherein R is a substituted alkyl or terpenyl, with hexamethylenetetramine in the presence of ammonium acetate in ethanol at its boiling temperature; said esters of acetoacetic acid of the above general formula, hexamethylenetetramine and ammonium acetate can be used in stoichiometric proportions.

2,6-Dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid esters and method

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Egils A Biseniex