Erregierre Industria Chimica S.p.a.

Erregierre S.p.a.

Egidio Molinari

Antonio Bonaldi

Aldo Roda

Massimo Ferrari

Fabrizio Zinetti

Vanna Springolo

Process for the preparation of derivatives having general formula (I) ##STR1## wherein the meaning of R will be defined in the text, characterized by the reaction between a compound having formula ##STR2## wherein X is an halogen, and an alkaline salt of a methyl dialkylmalonate.

Process for the preparation of .alpha.-methyl-2-thiopheneacetic acid

A process for the preparation of glycine-conjugated bile acids as general formula (I):

Process for the preparation of glycine-conjugated bile acids

Process for the preparation of taurine-conjugated biliary acids of general formula (I):

Process for the preparation of taurine-conjugated bile acids

A process for preparing the high-melting polymorph of terfenadine, characterized by dissolving terfenadine in a water-miscible polar solvent by heating to a temperature of between 40.degree. and 100.degree. C. The solution is then percolated into a sufficient quantity of water, kept stirring at ambient temperature, to cause substantial precipitation of the high-melting terfenadine polymorph.

Preparation of the high-melting polymorph of terfenadine

A process for preparing 3-.alpha.-7-.beta.-dihydroxycholanic acid from a crude product containing up to 15% by weight of 3-.alpha.-7-.alpha.-dihydroxycholanic acid and up to 1% by weight of 3.alpha.-hydroxycholanic acid, by esterifying with methanol, crystallizing from a mixture of solvents consisting of methanol, an aromatic solvent and water and recrystallizing from a mixture of methanol, aromatic solvent and water.

Process for preparing high purity 3-.alpha.-7-.beta.-dihydroxycholanic

A process for preparing alpha-(alkylphenyl)-4-(hydroxy diphenylmethyl)-1-piperidine butanols of formula (I) ##STR1## in which R is a C.sub.1 -C.sub.5 alkyl, by reacting an isonipecotate of formula (II): ##STR2## in which R' is a C.sub.1 -C.sub.5 alkyl or benzyl, with 1-(alkylphenyl)-4-chlorobutanol to obtain the compound (IV) directly ##STR3## and reacting (IV) with phenylmagnesium halide (V) to obtain (I).

Process for preparing alpha (alkyl

A process for preparing clotrimazole by reacting 2-chlorotriphenylmethylchloride with imidazole in a hydrocarbon solution in the presence of a neutralizing agent, followed by nitration of the product obtained. The nitrate is reconverted into the free base with caustic alkali.

Process for preparing clotrimazole

N-(trans-p-hydroxy-cyclohexyl)-(2-amino-3,5-dibromo)benzylamine salts possessing mucolytic activity, and having the general formula: ##STR1## wherein R is the anion of a mono or dicarboxylic amino acid chosen from the group consisting of .alpha.-mercaptopropionylglycine, S-benzoyl-.alpha.-mercaptopropionylglycine, S-thenoyl-.alpha.-mercaptopropionylglycine, acetyl-L-cysteine, carboxymethyl-L-cysteine, thiazolidinemonocarboxylic acid and thiazolidinedicarboxylic acid, and n is 1 if said amino acid is monocarboxylic, n is 1 or 2 if said amino acid is dicarboxylic.

N-(trans-p-hydroxy-cyclohexyl)-(2-amino-3,5-dibromo)benzylamine salts

Propionylanilides, and relative salts of addition, having the following general formula: ##STR1## The new compounds are useful in the treatment of morbid cold-induced forms.

Morpholine containing propionylanilides and pharmaceutical compositions

Salification products between cholic acids (chenodeoxicholic and ursodeoxycholic acid) and trimebutyne in the molar ratio 1:1 or 2:1 have been prepared. These new salts show a pharmacotherapeutic action, which, as a whole, is not found in other known drugs, and which makes them useful for the treatment of diskinesiae, biliary dyspepsiae, cholecystopathies, and for the normalization of the kinesis of the intestinal gastro-biliary tract.

Salification products of cholic acids with trimethoxy-3,4,5-benzoic

A process for preparing very pure ursodeoxycholic acid starting from cholic acid (I) by:

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Longone Al Segrino, Italy

Egidio Molinari