Bayer Aktiengesellschaft

Baker Aktiengesellshaft

Egbert Wehinger

Harald Horstmann

Eike Moller

Karl Meng

Friedrich Bossert

Horst Meyer

Kurt Stoepel

Stanislav Kazda

Wulf Vater

Arend Heise

Robertson Towart

Friedel Seuter

Andreas Knorr

Gerhard Franckowiak

Karl-August Meng, Deceased

Siegfried Goldmann

Bodo Junge

Karl Meng, Deceased

Rudolf Schohe-Loop

Thomas Glaser

Hans-Georg Heine

Hartmund Wollweber

Jean-Marie-Viktor De Vry

Henning Sommermeyer

Klaus Urbahns

Reilinde Wittka

Otto Behner

Klaus Schlossmann

Ulrich Benz

Jurgen Stoltefuss

Matthias Schramm

Horst Boshagen

Gunter Thomas

Bernward Garthoff

Stanislav Kaada

Stanislay Kazda

Friedrich Bosseret

The present invention relates to the use of 1,4-dihydropyridine-3,5-dicarboxylic acid esters, some of which are known, of the general formula (I) ##STR1## in which A and R.sup.1 -R.sup.3 have the meaning given in the description, as medicaments, in particular for treatment of the central nervous system, and new selected active compounds.

Use of 1,4-dihydropyridine-3,5-dicarboxylic acid esters as medicaments

1,4-dihydropyridine-3,5-dicarboxylic acid esters in treatment of

The invention relates to optically active 1,4-dihydropyridine compounds of Formulas Ia and Ib as defined hereinabove which are effective for influencing circulation. Also included in the invention are compositions containing said optically active compounds and methods for the use of said compounds and compositions.

Optically active 1,4-dihydropyridine esters useful for treating

The compound,

Hypotensive long-acting 1,4-dihydropyridines of the formula ##STR1## in which R.sup.1 is phenyl or heterocyclic,

Coronary-active fluorine-containing 1,4-dihydropyridines

Pyridinecarboxylic acid esters of the formula ##STR1## in which R is an optionally substituted aryl or heterocyclic radical,

Ischaemia or hypoxia controlling compositions containing

##STR1## in which optically pure products are obtained. The process is novel, as is II. I is known as being active on the blood circulation system.

Intermediates of optically active 1,4-dihydropyridines

A method of treating a patient suffering from asthma which comprises administering to such patient an asthma-relieving amount of a 5-sulphonyl-1,4-dihydropyridine of the formula ##STR1## in which R.sup.1 is aryl having 6 or 10 C atoms, optionally substituted by 1 to 3 identical or different substituents from the group: halogen, cyano, nitro, trifluoromethyl, trifluoromethoxy, alkoxycarbonyl (up to 4 C atoms), carboxyl, alkoxy (up to 4 C atoms) or straight-chain or branched alkyl having up to 4 C atoms, or is heteroaryl,

Use of sulphonyldihydropyridines as medicaments for the treatment of

##STR1## is a vaso-dilator effective in combating hypertension and circulatory disorders.

Isopropyl 2-(3-trifluoromethylphenoxy)-ethyl

Compounds of the formula ##STR1## in which R is an optionally substituted aryl or heterocyclic radical,

Asymmetric diesters of Hantzsch dihydropyridines with hypotensive

Pyridopyrimidines of the formula ##STR1## in which R.sup.1 is optionally substituted aryl or heterocyclic, exhibit circulation active properties, especially renal vasodilating and diuretic action.

Pyridopyrimidines, pharmaceutical compositions and use

1,2,3,4-Tetrahydropyridines of the formula ##STR1## in which R.sup.1 is optionally substituted aryl or heterocyclic,

Antihypertensive tetrahydropyridine 3,5 dicarboxylic acid esters

Dihydropyridines of the formula ##STR1## in which R is aryl or heterocyclic,

Certain nitratoalkyl ester dihydropyridines having antihypertensive

Antihypertensive tetrahydropyridine 3-cyano 5-carboxylic acid esters

The invention relates to 1,4-dihydropyridines as well as methods for the preparation of said 1,4-dihydropyridines and compositions contained therein. The invention also includes the use of said compounds and compositions for influencing circulation.

Vasodilating cyanoalkyl esters of 1,4-dihydropyridines

Growing community of inventors

Wuppertal, Germany

Egbert Wehinger