University of British Columbia

Ioulia & Irene Tseti Pharmaceutical Laboratories Industrial and Commercial S.a.

Efstathios Gonos

Martin E Gleave

Maxim Signaevsky

Eliana Beraldi

Burkhard Jansen

Ioannis P Trougakos

Theodora Calogeropoulou

Maria Koufaki

Niki Chondrogianni

Kyriakos Proussis

Theano Fotopoulou

Demetris Papahatjis

Evanthia Chazapi

RNAi sequences that are useful as therapeutics in the treatment of cancers of various types, including prostate cancer, sarcomas such as osteosarcoma, renal cell carcinoma, breast cancer, bladder cancer, lung cancer, colon cancer, ovarian cancer, anaplastic large cell lymphoma and melanoma; and Alzheimer's disease. These sequences target clusterin, IGFBP-5, IGFBP-2, both IGFBP-2 and -5 simultaneously, Mitf, and B-raf. The invention further provides for the use of these RNAi sequences in the treatment of cancers of various types, including prostate cancer, sarcomas such as osteosarcoma, renal cell carcinoma, breast cancer, bladder cancer, lung cancer, colon cancer, ovarian cancer, anaplastic large cell lymphoma and melanoma; and Alzheimer's disease, and a method of treating such conditions through the administration of the RNA molecules with RNAi activity to an individual, including a human individual in need of such treatment.

RNAi probes targeting cancer-related proteins

Growing community of inventors

Athens, Greece

Efstathios Gonos