Microdose Therapeutx, Inc.

Cytopathfinder, Inc.

Efrat Ben-Zeev

Sharon Shacham

Yael Marantz

Zhaoda Zhang

Dilara McCauley

Vincent Jacques

Oren Becker

Ashis K Saha

Pini Orbach

A Sekar Reddy

Michael Xie

Shomir Ghosh

Jian Lin

Dongli Chen

Pradyumna Mohanty

Steffi Koerner

Merav Fichman

Rosa E Melendez

Dilara Mccaulay

Provided are adenosine analog compounds such as that act as P2Y receptors, e.g., the P2Yreceptor, including pharmaceutical compositions; and uses thereof to treat or prevent diseases associated with that receptor, e.g., disorders relating to mucus secretion, such as cystic fibrosis, chronic obstructive pulmonary disorder (COPD), asthma, constipation, chronic idiopathic constipation, dry mouth (xerostomia), gum disease, and gastrointestinal problems caused by radiation and chemotherapy for cancer.

Adenosine analogs and their use

Provided are adenosine analog compounds of the general formula that act as P2Y receptors, e.g., the P2Yreceptor, including pharmaceutical compositions; and uses thereof to treat or prevent diseases associated with that receptor, e.g., disorders relating to mucus secretion, such as cystic fibrosis, chronic obstructive pulmonary disorder (COPD), asthma, constipation, chronic idiopathic constipation, dry mouth (xerostomia), gum disease, and gastrointestinal problems caused by radiation and chemotherapy for cancer. 

Chemokine receptor antagonists, in particular, compounds of Formula (I-A) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein. 

Carboxamide compounds and their use

Growing community of inventors

K. Motzkin, Israel

Efrat Ben-Zeev