Yale University

Efim Ilya Golub

Gurucharan Reddy

Charles Meyer Radding

David C Ward

Thomas Haaf

Sherman M Weissman

Peter M Rabinovich

Erkut Bahceci

Marina E Komarovskaya

Samuel Katz

Compositions and methods of making cells using RNA, and cells made using the disclosed compositions and methods are also provided. In exemplary embodiments, RNA is transfected into cells to effect a molecular, biological, physiological, or histological change in the cells. In preferred embodiments, the RNA is prepared in vitro, more preferably using a DNA template according to the provided compositions and methods. Methods for treating or inhibiting a disorder or disease such cancer are also provided. The methods can include, for example, locally or systemically administering to the host an effective amount of one or more RNAs; or an effective amount of population of cells isolated from the subject or a syngeneic or histocompatible subject, contacted ex vivo with one or RNAs, and optionally expanded. The cells can be, for example, immune cells or stem cells.

Cells prepared by transient transfection and methods of use thereof

Compositions and methods are provided for identifying and diagnosing individuals at risk for a disease state associated with aberrant Rad41 foci.

Methods and compositions utilizing Rad51

Compositions and methods are provided for identifying agents which bind to or modulate Rad51.

The invention relates to complexes of eukaryotic Rad52 protein and nucleic acids, and methods of using the complexes.

Growing community of inventors

New Haven, CT, United States of America

Efim Ilya Golub