Smithkline Beecham Corporation

Other

Edwina Imogen Wilding

Michael N Gwynn

Michael Terence Black

Min Wang

Deborah Dee Jaworski

Lisa Kathleen Shilling

Anna Lisa Kosmatka

Christopher Michael Traini

Neil David Pearson

Mihai-Serban Iordanescu

Richard Lloyd Warren, Jr

Symon G Erskine

A method of modulating the activity of a aberrant cell topoisomerase enzyme involving contacting the enzyme with a compound that inhibits enzyme-mediated cleavage of a polynucleotide substrate with which the enzyme is in complex. Pharmaceutical compositions containing such compounds may be used to treat neoplasias or to inhibit the growth of certain cancer cells. Screening methods can be employed to identify other compounds for these uses.

Compounds and methods for the treatment of neoplastic disease

The invention provides nrdE polypeptides and polynucleotides encoding nrdE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing nrdE polypeptides to screen for antibacterial compounds.

NRDE

The invention provides pskG polypeptides and polynucleotides encoding pskG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pskG polypeptides to screen for antibacterial compounds.

pskG

The invention provides gyrA polypeptides and polynucleotides encoding gyrA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gyrA polypeptides to screen for antibacterial compounds.

GyrA

The invention provides mevalonate kinase (hereinafter &ldquo;MVK&rdquo;) polypeptides and polynucleotides from,encoding mvk polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing mvk polypeptides to screen for antibacterial compounds.

Polynucleotides encoding mevalonate kinase from Streptococcus pneumoniae

NrdE of staphylococcus aureus

The invention provides nrdF polypeptides and polynucleotides encoding nrdF polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing nrdF polypeptides to screen for antibacterial compounds.

Ribonucleotide diphosphate reductase, nrdF, of streptococcus pneumoniae

The invention provides ispA polypeptides and polynucleotides encoding ispA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ispA polypeptides to screen for antibacterial compounds.

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Paoli, PA, United States of America

Edwina Imogen Wilding