Abbott Laboratories Corporation

Edwin Samuel Johnson

Akwete L Adjei

John Hunter Seely

James W Kesterson

Riemond Henry Rippel, Jr

Wilfrid Francis White

The invention relates to novel solution and suspension aerosol formulations comprising LHRH analogs.

LHRH analog formulations

The invention relates to novel aerosol formulations comprising LHRH analogs, a lipophilic counterion, solvent and propellant and, optionally, surfactant, valve lubricant, an antioxidant and flavor and fragrance.

Certain nonapeptide amides were found which, upon administration at daily dosages of from about 1-200 .mu.g/kg to warm-blooded animals, cause regression of DMBA-inducible or mammary tumors without causing adverse effects on healthy tissues.

Treatment of a mammary or DMBA inducible tumor

With the administration of 1 .mu.g - 10mg/kg of specified nonapeptides, reproduction is prevented in warm-blooded animals of the reproductive age.

Method to prevent reproduction in warm-blooded female animals with

Certain nonapeptides have been found to induce parturition in warm-blooded animals if administered within the last phase of pregnancy.

Parturition inducement

With the administration of 2 - 200 .mu.g./kg. of a nonapeptide, reproduction is prevented in warm-blooded animals of the reproductive age.

Method to prevent reproduction with [Des-Gly].sup.10 -GN-RH nonadeptide

A series of nonapeptide amides has been found which, upon administration at daily doses of from about 1-500 .mu.g/kg to male warm-blooded animals, cause regression and subsequent elimination of prostatic hyperplasia without causing adverse effects to healthy tissues.

Treatment of prostatic hyperplasia

A series of nonapeptide amides has been found which, upon administration at daily dosages of from about 1-200 .mu.g/kg to warm-blooded animals, cause regression and subsequent elimination of certain tumors without causing adverse effects on healthy tissues.

Growing community of inventors

Antioch, IL, United States of America

Edwin Samuel Johnson