Smith Kline & French Laboratories Limited

Edwin Michael Taylor

Robert A Slater

Anthony Maitland Roe

William J Coates

Substituted derivatives of 3-chloro-6-phenylpyridazine which are useful intermediates in the preparation of substituted phenylhydrazinopyridazines which have .beta.-adrenergic blocking and vasodilator activity.

3-Chloro-6-phenylpyridazine compounds

Substituted phenyl pyridazinethiones which are useful intermediates in the preparation of substituted phenylhydrazinopyridazines which have .beta.-adrenergic blocking and vasodilator activity.

Pyridazinethiones

The compounds are substituted hydrazinophthalazines which are active as .beta.-adrenergic blocking agents and as vasodilators. A specific compound of the invention is 5-(3-t-butylamino-2-hydroxypropoxy)-1-hydrazinophthalazine.

(3-Alkylamino-2-hydroxypropoxy)-1-hydrazinophthalazines

The compounds are 3-(3-(3-substituted amino-2-hydroxypropoxy)phenyl)-6-hydrazino pyridazines which have .beta.-adrenergic blocking and vasodilator activity.

3-(3-(3-Substituted amino-2-hydroxypropoxy)phenyl)-6-hydrazino

The compounds are 3-((3-substituted amino-2-hydroxypropoxy)-phenyl)-6-hydrazino pyridazines which have .beta.-adrenergic blocking and vasodilator activity.

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Welwyn, United Kingdom

Edwin Michael Taylor