Kreatech Diagnostics

Edwin Leo Lempers

Jan Reedijk

Hendrik Jan Houthoff

Tinka Jelsma

Remco Maria Van Es

Franciscus Michiel Van Den Berg

Marieke Johanna Bloemink

The invention provides platinum-based probe compounds having the structure: ##STR1## wherein: Pt is a platinum atom, PROBE is a probe biomolecule for associating to a target biomolecule, M is a detectable marker moiety, and X and Y are stabilizing substituents. Also provided are platinum-based labeling compounds having the structure: ##STR2## wherein: Pt is a platinum atom, M is a detectable marker moiety, A is a displaceable leaving group, and X and Y are stabilizing substituents. The invention further provides platinum-based linker compounds having the structure: ##STR3## wherein: Pt is a platinum atom, A and B are the same or different reactive moieties, and X and Y are stabilizing substituents. Other Pt.sup.II and Pt.sup.IV compounds are also provided. Moreover, the invention provides methods for the preparation and use of these compounds, as well as diagnostic kits which contain the compounds.

Platinum-containing compounds methods for their preparation and

Platinum-containing compounds, methods for their preparation and

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Julianadorp, Netherlands

Edwin Leo Lempers