Hoffmann-La Roche Inc.

Madrigal Pharmaceuticals, Inc.

F. Hoffmann-La Roche Ag

Edwin L Crow

Charles Howard Reynolds

Ping Wang

Martha Jean Kelly

Robert J Duguid

Rebecca Taub

Lianhe Shu

Duk Soon Choi

D Keith Hester, Ii

Anna Chasnoff

Gang Dong

D Keith Hester

Charles H Reynolds

Martha Kelly

Keith D Hester

The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TR&#x3b2; mutation.

Methods of synthesizing thyroid hormone analogs and polymorphs thereof

Method of synthesizing thyroid hormone analogs and polymorphs thereof

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Santa Fe, NM, United States of America

Edwin L Crow