Exelixis Patent Company LLC

Exelixis, Inc.

Merck + Co., Inc.

X-ceptor Therapeutics, Inc.

Sankyo Company, Limited

Edwin J Schweiger

Raju Mohan

William C Stevens, Jr

Yinong Xie

Richard Martin

Michael Charles Nyman

Tie-Lin Wang

Brenton Todd Flatt

Brett Bradley Busch

Shao Po Lu

Xiao-Hui Gu

Alan Thomas Johnson

Haixia Wang

Christopher D Bayne

Shao-Po Lu

Wei Xu

Ian A McDonald

Jean-Michel Andre Vernier

Venkataiah Bollu

Vasu Jammalamadaka

Ping Huang

Nicholas David Peter Cosford

Brant Clayton Boren

Satoru Kaneko

Jackline Eve Dalgard

Rowena Villanueva Cube

Kozo Oda

Leo Solomon Bleicher

Tie Lin Wang

Xiao Hui Gu

Alan T Johnson

Kozo Sankyo Co Ltd Oda

Methods of using compounds of the invention, such as compounds of Formulae IIa, IIb, IIc, or IId and pharmaceutically acceptable salts thereof are disclosed. The compounds are useful in treating, preventing, inhibiting or ameliorating the symptoms of a disease or disorder that is modulated or otherwise affected by nuclear receptor activity, or in which nuclear receptor activity is implicated.

Imidazole based LXR modulators

Compounds of the invention, such as compounds of Formulae Ia, Ib, Ic, or Id and pharmaceutically acceptable salts, isomers, and prodrugs thereof, which are useful as modulators of the activity of liver X receptors, where R1, R2, R21, R3, and G are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed. 

Modulators of LXR

Compounds of the invention, such as compounds of Formulae IIa, IIb, IIc or IId, and pharmaceutically acceptable salts, isomers, and prodrugs thereof, are useful as modulators of the activity of liver X receptors, where R, R, R, Rand G are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed. 

A compound according to Formula I: or a pharmaceutically acceptable salt thereof, wherein R, R, R, Land X are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.

11 &#x3b2;-HSD1 modulators

Compounds of the invention, such as compounds of formula (I): 

Compounds of the invention are disclosed, such as compounds of formulae LX-LXIV, and pharmaceutically acceptable salts, isomers, or prodrugs thereof, which are useful as modulators of the activity of liver X receptors (LXR) and Farnesoid X receptors (FXR), where R, R, R, R, J, J, G, G, and Q are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed. 

LXR and FXR modulators

Compounds of formula (I): wherein n, R, R, Rand Rare disclosed herein, are useful in treating disease-states associated with nuclear receptor activity. Pharmaceutical compositions comprising and methods of using said compounds are also disclosed herein.

Isoquinolinone derivatives and their use as therapeutic agents

In accordance with the present invention, there is provided a novel class of heterocyclic compounds. Compounds of the invention contain a substituted, unsaturated five, six or seven membered heterocyclic ring that includes at least one nitrogen atom and at least one carbon atom. The ring additionally includes three, four or five atoms independently selected from carbon, nitrogen, sulfur and oxygen atoms. The heterocyclic ring has at least one substituent located at a ring position adjacent to a ring nitrogen atom. This mandatory substituent of the ring includes a moiety (B), linked to the heterocyclic ring via a carbon-carbon double bond, a carbon-carbon triple bond or an azo group. The mandatory substituent is positioned adjacent to the ring nitrogen atom. Invention compounds are capable of a wide variety of uses. For example heterocyclic compounds can act to modulate physiological processes by functioning as agonists and antagonists of receptors in the nervous system. Invention compounds may also act as insecticides, and as fungicides. Pharmaceutical compositions containing invention compounds also have wide utility.

Thiazolyl(pyridyl)ethyne compounds

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Edwin J Schweiger