University of Tennessee Research Foundation

The United States of America As Represented by the Department of Health

Univ. of Tennessee Research Corp.

Edwin H Beachey

Michael A Kehoe

Thomas P Poirier

Louis A Chedid

Francoise Marguerite Audibert

James B Dale

Andre Tartar

Helene Gras-Masse

Michel Jolivet

Non-virulent aro-Salmonella typhimurium bacterium is disclosed into which has been cloned a heterologous nucleotide sequence encoding for the expression of Streptococcal M protein antigen from S. pyogenes seratype 5, which is effective to elicit opsonic antibodies against Streptococcal infections. The bacterium is useful for vaccination against Streptococcus pyogenes bacteria.

Therapeutic compositions against streptococcal infections, transformed

Non-virulent bacteria are disclosed into which have been cloned heterologous nucleotide sequences encoded for the expression of Streptococcal M protein antigens, which are effective to elicit opsonic antibodies against Streptococcal infections. These bacteria are useful for vaccination against Streptococcus pyogenes bacteria.

Synthetic peptide segments of protein Pep M5 containing epitopes capable of evoking type specific opsonic antibodies against streptococci when covalently linked to a protein carrier.

Synthetic M proteins-streptococci type 5

A polypeptide having the formula Asn-Phe-Ser-Thr-Ala-Asp-Ser-Ala-Lys-Ile-Lys-Thr-Leu-Glu-Ala-Glu-Lys-Ala-Al a-Leu-Ala-Ala-Arg-Lys-Ala-Asp-Leu-Glu-Lys-Ala-Leu-Glu-Gly-Ala-Met is conjugated to polylysine.

Type-specific opsonic antibodies evoked with a synthetic peptide of

Synthetic immunogenic peptides when linked to a suitable carrier elicit opsonic antibodies which are type specific for type IV streptococci are disclosed.

Synthetic M proteins - streptococci type 6

Peptide fragment of M protein of S. pyrogenes elecit opsonic antibodies which are type-specific for type 24 streptococci.

Synthetic peptide compounds

Peptide fragments of streptococcal M protein named CB3, CB4, and CB5 and related synthetic peptides have been identified. When linked to a protein carrier which is polylysine the conjugates of CB3, CB4, CB5, and S-CB3 are capable of evoking type specific opsonic antibodies against streptococci.

Synthetic polypeptide fragments

Synthetic peptides corresponding to antigenic determinants of the M protein of streptococcus pyogenes are disclosed. These peptides are useful for vaccination against streptococcus pyogenes bacteria.

Synthetic peptides corresponding to antigenic determinants of the M

Certain peptide fragments of streptococcal M protein named CB6 and CB7 have been linked to a protein carrier which is polylysine. The conjugate has proved immunogenic in rabbits producing protective antibodies against the whole group A streptococcus.

Growing community of inventors

Memphis, TN, United States of America

Edwin H Beachey