Leland Stanford Junior University

Novocure Gmbh

Edwin Chang

Sanjiv Sam Gambhir

Moshe Giladi

Tali Voloshin-Sela

Chirag B Patel

John P Cooke

Parag Mallick

Joseph C Wu

Yaara Porat

Arutselvan Natarajan

Mirwais Wardak

Lingyun Xu

Nick Hughes

Carsten H Nielsen

Martin Ng

Jenny C Wu

Certain substances (e.g., large molecules) that ordinarily cannot traverse the cell membrane of cells can be introduced into cells by applying an alternating electric field to the cell for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the cell membrane. Once the permeability of the cell membrane has been increased, the substance is able to cross the cell membrane. This approach is particularly useful in the context of cancer cells (e.g., glioblastoma).

Using alternating electric fields to increase cell membrane permeability

The present disclosure provides methods of treating cancer and modifying a cancer treatment for a cancer with an anti-EGFR drug by creating PRDX6 expression profiles and using the profiles to evaluate and optionally modify treatment. The present disclosure also provides assays and systems for assessing sensitivity of a cancer to an anti-EGFR therapy.

Methods of treating cancer sensitive to anti-EGFR therapy and modifying treatment using peroxiredoxin 6 biomarker

The present invention provides methods of modulating angiogenesis in an individual, as well as methods of identifying a candidate agent that modulates angiogenesis, where such methods involve modulating and identifying agents that modulate expression of gene products of a subset of genes concordantly-regulated by agonists of nicotinic acetylcholine receptor (nAChR), bFGF receptor, and VEGF receptor.

Methods of modulating angiogenesis and screening compounds for activity in modulating angiogenesis

Growing community of inventors

Menlo Park, CA, United States of America

Edwin Chang