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The Charles Stark Draper Laboratory, Inc.

Edwin Carlen

Marc Steven Weinberg

Jeffrey T Borenstein

Jonathan Jay Bernstein

John Gregory Aceti

Malinda M Tupper

Christopher E Dubé

Ralph Hopkins

Angela Z Uhland

A sensor may include a substrate that has a cavity formed in a surface thereof. A diaphragm, having a conductive portion, may be suspended over the cavity, a selective coating may be present on a face of the diaphragm outside of the cavity, and a counterelectrode may be spaced from and in opposition to the diaphragm. The diaphragm may deform upon interaction of the selective coating with an analyte and thereby alter a capacitance of the sensor in a manner indicative of a degree of interaction.

Accessible stress-based electrostatic monitoring of chemical reactions and binding

Electrostatic capacitance measurements are used to detect chemical or biological analytes, or chemical interactions, with great sensitivity. A diaphragm is coated with a material capable of selectively interacting with an analyte of interest, and interaction of the analyte with the coating exerts stresses tangential to the diaphragm's surface. These stresses cause diaphragm displacements that are sensed as varying capacitance.

Stress-based electrostatic monitoring of chemical reactions and binding

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Enschede, Netherlands

Edwin Carlen