Interpore International

Other

Edwin C Shors

Eugene W White

Frederick L Hall

Marcel E Nimni

Bo Han

Lingtau Wu

Jack C Debes

Clayton G Harris

An improved porous ceramic biomaterial is disclosed in which a polymer such as polylactic acid is polymerized in situ to fill the micropores substantially without filling the macropores. The polymer reinforcement helps improve the strength of the implant while preserving its ability to support ingrowth of bone to help integrate the implant into its surgical environment.

Porous biomaterials and methods for their manufacture

A bone morphogenetic fusion protein and a method of preparation of the bone morphogenetic fusion protein. The bone morphogenetic fusion protein comprises a purification tag and a bone morphogenetic active fragment. A method of preparing bone morphogenetic fusion protein comprises purifying and renaturing bone morphogenetic protein to provide an active bone morphogenetic fusion protein preparation. Methods of use of the bone morphogenetic fusion protein are also provided.

Bone morphogenetic proteins and their use in bone growth

Biomaterials useful for onthopedicanel dental applications is disclosed. These materials have a base portion of calcium carbonate and a surface layer of a synthetic phosphate such as hydroxyapatite. The base portion may be a calcium carbonate structure having three-dimensional interconnected porosity such as may be found in porous skeletal carbonate of marine life, e.g. coral porites skeletal aragonite, or it may be porous or non-porous granules of calcium carbonate. A method for making the biomaterials is also disclosed. The synthetic phosphate surface is made using a hydroconversion reaction with a soluble or solubilized phosphate such as ammonium dibasic phosphate ((NH4).sub.2 HPO4).

Coated biomaterials and methods for making same

A prosthesis for replacing parts of arteries and other blood vessels preferably has an inner tube suitable for use as a vascular graft in combination with external longitudinal ribs and a surrounding wrap which provides radial and longitudinal strength and resistance to kinking. The ribs separate the wrap from the inner tube, providing spaces between the wrap and tube to allow the tube to expand and contact, thus promoting isocompliance of the prosthesis with natural blood vessels.

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Costa Mesa, CA, United States of America

Edwin C Shors