Princeton University

Affymetrix, Inc.

Edward Yat Tom

Kurt C Gish

David H Mack

Arnold J Levine

Maureen Elizabeth Murphy

Many genes are identified as being p53-regulated which were not heretofore known to be p53-regulated. This includes both genes whose expression is induced and genes whose expression is repressed by the expression of wild-type p53. Monitoring expression of these genes is used to provide indications of p53 status in a cell. Such monitoring can also be used to screen for useful anti-cancer therapeutics, as well as for substances which are carcinogenic. Defects in p53 can be bypassed by supplying p53 induced genes to cells. Defects in p53 can also be bypassed by supplying antisense constructs to p53-repressed genes.

Growing community of inventors

Sacramento, CA, United States of America

Edward Yat Tom