National Institutes of Health, a Component of the US Dept. of Health & Human Services

Other

The United States of America As Represented by the Department of Health

The United States of America As Represented by the Dept. of Health &

Edward Wellner

Paul D Smith

Paul Reed Smith

Amir H Gandjbakhche

David Hattery

Victor Chernomordik

Norman Salzman

Jim Mulshine

Gary D Hodgen

Francisco De Monasterio

Maria Michejda

Jorge L Juncos

An eye examination device has a fundus observation system and an optical stimulation system. The optical stimulation system has an optical targeting subsystem and an optical stimulation subsystem, wherein the optical stimulation system is structured to be used to provide light stimulation to a portion of a fundus of an eye targeted by the optical targeting subsystem in conjunction with observations made with the fundus observation system.

Fundus photo-stimulation system and method

The invention provides a device and method for monitoring inflammation of the epithelium. The device consists of a head region, a handle region and an optical bundle. At least two of the optical fibers in the bundle are utilized as a source of radiation, these two fibers are at two different angles from normal. At least one of the other optical fibers is utilized as a detector for the reflected radiation, or alternatively an image guide can be used as the detector. The device of the invention can be part of an external or internal system that can include a light source, the device, a multiplexer, a spectrometer, and a computer for data analysis. The method of the invention allows for the detection and monitoring of general inflammation of the oral epithelium. The inflammation of the epithelium can be detected or monitored to diagnose diseases of the oral epithelium, monitor such diseases, monitor treatment of such diseases, or pre-screen for and monitor preventative treatments of such diseases.

Methods of detecting inflammation of an epithelium layer in the oral region with a probe using diffuse-reflectance spectroscopy

Probe using diffuse-reflectance spectroscopy

A cold plate for maintaining specimen samples for dissection at desired cooled temperatures includes a metal plate having an aperture therethrough to receive a removable dark frosted glass piece capable of transmitting light therethrough. The metal plate is equipped with an integrally embedded hollow matrix of tubing to circulate a cooling medium delivered from a remotely operated refrigeration system. In addition, a remotely-operated lighting system is provided to illuminate the dark frosted glass piece and the surrounding regions.

Cold plate for laboratory use

A body coordination training aid is presented for providing audio signals to a user in response to the user's head and shoulders assuming a predetermined relative orientation. This is accomplished via an electronic device responsive to a movable electrode contacting an adjustable electrode to complete an electrical circuit.

Body coordination training aid

A hydrocephalic drainage valve consisting of a hollow shank with a pointed conical tip. The shank has an intake port adjacent the conical tip. A ball check valve in the shank is urged by a coiled spring toward closing relationship with the port. A hollow set screw is adjustably mounted in the shank to vary the biasing force on the valve ball. In one form, for manual implantation, a sleeve is slidably mounted on the shank, has a centrally apertured enlarged head and has implantation enlarged threads near the head. The head has aligned opposite radial grooves which are engageable by a manual insertion tool. In other forms, for pneumatic insertion, the shank has an enlarged head, employed as a driving piston in a pneumatic insertion tube. A washer member with implantation barbs is slidably mounted on the shank and is arranged to be locked to the shank subjacent the head responsive to the pneumatic driving action, with its barbs embedded in the fetal skin around the implantation puncture, thus holding the shank in operating position with the intake port exposed in the cranial vault.

Hydrocephalic antenatal vent for intrauterine treatment (HAVIT)

A body coordination training aid is presented for providing audio signals to a user in response to the user's head and shoulders assuming a predetermined relative orientation. This is accomplished via an electronic circuit responsive to a first electrode contacting a second electrode to complete an electrical circuit.

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Fairfax Station, VA, United States of America

Edward Wellner