Other

Applied Analytical Industries, Inc.

Edward S Wilson

Glenn A Meyer

Frederick D Sancilio

Ashok J Desai

Christy M Clark

Laura A Trespidi

Thomas W Leonard

James Swarbrick

Jonathan Pace

David P Hause

The present invention is a method for detecting and isolating fault modes in a system having a model describing its behavior and regularly sampled measurements. The models are used to calculate past and present deviations from measurements that would result with no faults present, as well as with one or more potential fault modes present. Algorithms that calculate and store these deviations, along with memory of when said faults, if present, would have an effect on the said actual measurements, are used to detect when a fault is present. Related algorithms are used to exonerate false fault modes and finally to isolate the true fault mode. This invention is presented with application to detection and isolation of thruster faults for a thruster-controlled spacecraft. As a supporting aspect of the invention, a novel, effective, and efficient filtering method for estimating the derivative of a noisy signal is presented.

Model-based fault detection and isolation for intermittently active faults with application to motion-based thruster fault detection and isolation for spacecraft

The present invention is a method for identifying unknown parameters in a system having a set of governing equations describing its behavior that cannot be put into regression form with the unknown parameters linearly represented. In this method, the vector of unknown parameters is segmented into a plurality of groups where each individual group of unknown parameters may be isolated linearly by manipulation of said equations. Multiple concurrent and independent recursive least squares identification of each said group run, treating other unknown parameters appearing in their regression equation as if they were known perfectly, with said values provided by recursive least squares estimation from the other groups, thereby enabling the use of fast, compact, efficient linear algorithms to solve problems that would otherwise require nonlinear solution approaches. This invention is presented with application to identification of mass and thruster properties for a thruster-controlled spacecraft.

Multiple concurrent recursive least squares identification with application to on-line spacecraft mass-property identification

A device and method for reducing wear and stress in the string of a stringed instrument, such as a guitar. Certain stringed instruments are strung by advancing strings through string apertures in the body of the instrument. The device includes tubular sleeves that are placed into the string apertures. As the instrument is strung, the strings of the instrument are tightened. When tightened, the strings abut against and bend around the tubular sleeve. The tubular sleeve has a curved surface against which the strings bend. This lowers stress concentrations in the strings at the points of the bend. Furthermore, the tubular sleeves are made from a material that is softer than the material of the instrument's strings. Accordingly, as the instrument's strings wear against the sleeves, the sleeves experience the wear more so than the strings.

Protective sleeve for an instrument string and its method of application to an instrument

The invention is directed to shrink wrapping a casket to be entombed, including an article of a shrink wrapped casket with a ventilation port including a filter and a method comprising steps of sealing the wrap with shrink wrap tape and providing two-way ventilation by placing a ventilation filter that is impenetrable to the phorid fly. This invention overcomes problems associated with the entombment of caskets in aboveground mausoleum crypts, such as fluids escaping from the casket and phorid fly infestations.

Shrink-wrap casket shield

The present invention relates to novel, liquid and semi-solid pharmaceutical compositions which can be administered in liquid form or can be used for preparing capsules containing such pharmaceutical compositions. Also provided are methods of using and processes for preparing the pharmaceutical compositions of the present invention.

Oral liquid compositions

Methods of forming solid pharmaceutical compositions comprise solubilizing water-soluble polymers and amino acid-based components having molecular weights ranging from about 100 daltons to about 200,000 daltons or pharmaceutically acceptable salts thereof in solvents; and separating the solvents from the water-soluble polymers and the amino acid-based components or pharmaceutically acceptable salts thereof to form solid pharmaceutical compositions comprising the water-soluble polymers and the amino acid-based components or pharmaceutically acceptable salts thereof.

Spray drying of pharmaceutical formulations containing amino acid-based

The present invention provides pharmaceutical capsule compositions for the oral administration of an H.sub.2 -antagonist. The composition includes a capsule containing an emulsion having a water portion and an oil portion. A pharmaceutically acceptable salt of an H.sub.2 -antagonist is dissolved in the water portion. The composition delivers a therapeutically effective amount of the H.sub.2 -antagonist to a patient in need thereof. The present invention also provides methods of making the capsule composition.

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Wilmington, NC, United States of America

Edward S Wilson