Boehringer Ingelheim Pharmaceuticals, Inc.

Boehringer Ingelheim Vetmedica Gmbh

Edward S Lazer

Clara K Miao

Julian Adams

Peter Farina

Cornelia Dorner-Ciossek

Klaus Klinder

Charles Lawrence Cywin

Ronald John Sorcek

Marcus Kostka

Klaus Bornemann

Frank Sams-Dodd

Dagmar Kugler

Guenter Trummlitz

Bernd Beck

A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid &#x3b2; peptides (A&#x3b2;) and/or with a changed ratio of levels of A&#x3b2; isoforms and/or with the formation of plaques containing amyloid &#x3b2; peptide (A&#x3b2;) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas Ia, Ib wherein V, W, Y, R, R, R, R, L1 and i are defined as in claim

Method of treating diseases and conditions associated with an altered level of amyloid &#x3b2;  peptides and new enolcarboxamide compounds

Antiinflammatory compounds of the formula I or IA ##STR1## wherein, R.sub.1 is hydrogen, halogen, C.sub.1-4 alkyl, or C.sub.1-4 alkoxy; R.sub.2 and R.sub.3 are the same or different and each is hydrogen, halogen, trifluoromethyl, C.sub.1-4 alkyl, or C.sub.1-4 alkoxy; and, R.sub.4 is C.sub.3-4 alkyl, C.sub.1-4 -trifluoroethyl, 2-thienyl, 2-naphthyl, phenyl or phenyl mono- or disubstituted with C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, trifluoromethyl, or nitro.

2-benzyl-4-sulfonyl-4H-isoquinolin-1,3-diones and their use as

Various substituted benzoxazoles and benzothiazoles, are described and disclosed, which are potent inhibitors of leukotriene synthesis in warm-blooded animals.

Leukotriene biosynthesis inhibitors

Various substituted benzoxazoles, benzothiazoles, oxazolopyridines and thiazolopyridines are described and disclosed, compounds that are potent inhibitors of leukotriene synthesis in warm-blooded animals.

The present invention discloses 3-[2-(3',5'-di-tert-butyl-4'-hydroxyphenyl)ethenyl]pyridine and its use in treating inflammation, particularly chronic inflammatory diseases such as arthritis, and allergic disorders.

3-[2-(3',5'-di-t-butyl-4'-hydroxyphenyl)ethenyl]pyridine

3-[2-(3',5'-di-t-butyl-4'-hydroxyphenyl)ethenyl]pyridine having

Disclosed are novel 2-(2,2,2-trifluoroethylsulfonyl)-1H-benzimidazoles represented by formula I ##STR1## wherein R.sub.1 and R.sub.2 are each independently hydrogen, halogen or C.sub.1 -C.sub.2 lower alkyl and nontoxic, pharmaceutically acceptable salts thereof as well as the corresponding trifluoroethylmercapto compounds which are useful as intermediates in making the compounds of Formula I. The compounds of Formula I can be used for the treatment of chronic inflammation and inflammatory diseases such as rheumatoid arthritis.

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Trumbull, CT, United States of America

Edward S Lazer