Kci Licensing, Inc.

Ic Surgical, Inc.

Lifecell Corporation

Stembiosys, Inc.

Lifecell Coporation

Edward S Griffey

Colin John Hall

Jonathan Kagan

Michael E Manwaring

Douglas A Cornet

Charles Alan Seegert

Erin Black

Travis Block

Larry Tab Randolph

Stephen A Livesey

Christopher Guy Coward

Royce W Johnson

Hui Xu

A David Boccuti

Andrew Nicholas Gentile

Charles M Schiff

Herbert Daniel Beniker

David J McQuillan

Todd Herron

Lawrence E Boerboom

Mary M Navarro

Teryl Blane Sanders

Hugo A Pedrozo

Blane Sanders

Christopher Kaufmann

Abhijit Nag

Anthony A Del Campo

Ken B Nichols

Christopher Coleman

Christopher R Kaufmann

David J Mcquillan

Disclosed are methods of using a cell-derived extracellular matrix derived in-vitro from cells isolated from amniotic fluid (AFC-ECM) for the maturation of immature cardiomyocytes derived from human induced pluripotent stem cells (immature hiPSC-CMs) in culture forming mature cardiomyocytes. Also disclosed is a cell construct comprising a monolayer of these mature cardiomyocytes on an AFC-ECM useful for cardiotoxicity and/or proarrhythmic screening assays of drug compounds. Also disclosed are methods for determining the cardiotoxicity and/or proarrhythmic effect of a drug compound in vitro using such cell constructs.

Methods for the maturation of cardiomyocytes on amniotic fluid cell-derived ECM, cellular constructs, and uses for cardiotoxicity and proarrhythmic screening of drug compounds

Disclosed is a cell-derived extracellular matrix (ECM) derived in vitro from cells isolated from amniotic fluid, and methods of use for the isolation, maintenance, and proliferation of adherent cells including stem cells, as well as for the differentiation of stem cells.

Amniotic fluid cell-derived extracellular matrix and uses thereof

Provided are drainage systems that may include a drainage manifold and may be suitable for draining fluid from a tissue site. The drainage manifold may include a plurality of elongate members having a moveable end that may be adapted to configure the drainage manifold to treat a uniquely shaped tissue site. The drainage manifold may be coupled to a drainage tube with a transitional connector to provide a drainage system capable of distributing reduced pressure to the tissue site to enhance the drainage of fluids.

Adaptable wound drainage system

Disclosed herein are methods of using a cell-derived extracellular matrix derived in-vitro from cells isolated from amniotic fluid (AFC-ECM) for the maturation of immature cardiomyocytes derived from human induced pluripotent stem cells (immature hiPSC-CMs) in culture forming mature cardiomyocytes. Also disclosed herein is a cell construct comprising a monolayer of these mature cardiomyocytes on an AFC-ECM useful for cardiotoxicity and/or proarrhythmic screening assays of drug compounds. Also disclosed herein are methods for determining the cardiotoxicity and/or proarrhythmic effect of a drug compound in vitro using such cell constructs.

A reduced-pressure treatment system for treating a wound on a patient includes a composite manifold that may help prevent or minimize injury to a wound edge of the wound being treated with reduced pressure. The composite manifold includes a perimeter manifold member and an inboard manifold member. The perimeter manifold member is designed to not collapse substantially under reduced pressure in a therapy range. The perimeter manifold member may be more rigid with respect to compressibility than the inboard manifold member. A sealing member is used to form a fluid seal over the wound, and a reduced-pressure subsystem provides reduced pressure to the composite manifold. Other systems, methods, and dressings are presented.

Reduced-pressure, composite manifolds

Tissue scaffolds are described herein. Also described are devices for treating wounds and methods of treating wounds using tissue scaffolds.

Tissue scaffolds

A system for applying a treatment to a defect in one bone of two bones forming a joint that comprises a bladder for delivering a reduced pressure to the defect and for providing a positive pressure as bracing between the two bones of the joint is disclosed. A method for applying such treatment is also disclosed. A bladder for applying such treatment that comprises a reduced-pressure chamber and a bracing chamber is also disclosed.

Reduced pressure augmentation of microfracture procedures for cartilage repair

The present invention provides skin grafting and devices that comprise a systematic approach to the process of skin grafting, i.e., harvesting, post-excision processing and application of donor skin and pre and post-graft treatment of the recipient site.

Skin grafting devices and methods

Growing community of inventors

Fair Oaks Ranch, TX, United States of America

Edward S Griffey