Pioneer Surgical Technology, Inc.

Massachusetts Institute of Technology

Anika Therapeutics, Inc.

Angstrom Medica

Rti Surgical, Inc.

Edward S Ahn

Brian M Schlossberg

Juchui Ray Lin

Jackie Yi-Ru Ying

Atsushi Nakahira

Stephen M Capistron

Hansen A Yuan

Francis Vincent Lamberti

Ronald Stewart Hill

Adam MacMillan

William H Lloyd

Steven W Ek

John F Cvinar

Chia-En Lin

Paul Mraz

Atsuski Nakahira

Matthew M Mannarino

Sonali Puri

Stephen J Kennedy

Paul J Mraz

Robert Richard

Elvira Marchetto

Stefano Agnello

Sara Simoncioni

Colin D White

Matteo Centola

Sekoni Daouda Noel

A bioabsorbable textile for the restoration of the joint function whereas the joint is affected by partial thickness tears, small to medium full-thickness tears, large to massive full-thickness tears, acute and chronic/degenerative tears. The bioabsorbable textile may comprise polymeric yarns interconnected to form a weave or knitted configuration, wherein said bioabsorbable textile provides a combined mechanical and biological augmentation in the target joint tissue. The bioabsorbable textile may be implanted in combination with fixation tools during open, mini-open or arthroscopic repair/augmentation procedures of joint tissue tears.

Bioabsorbable textiles and methods for joint function restoration

Disclosed are cement products, methods of forming cement using the cement product, and methods of using the cement product in orthopedic and dental applications. Generally, the disclosed cement product includes a first component and a second component. The first component comprises a polymerizable resin comprising ethylenic unsaturated double bond, a suitable glycidyl group and/or a suitable isocyanate group. The second component includes a compound comprising more than one type of amine selected from the group consisting of primary amine, secondary amines, tertiary amines and quaternary amines. Alternatively, the second component includes a compound comprising a suitable mercapto (SH&#x2014;) group, a hindered amine or a dimethylthiotoluenediamine (DMTDA). Optionally, the cement product includes a filler and/or a bioactive component to promote bone formation.

Cement products and methods of making and using the same

Injectable compositions and methods for treating an injured tendon in an animal or human are disclosed herein. The injectable compositions include an effective amount of a carbohydrate to increase osteotendinous hydration and lubrication.

Methods and compositions for treating tendon degeneration

Methods for the synthesis of tricalcium phosphates are presented, as well as a series of specific reaction parameters that can be adjusted to tailor, in specific ways, properties in the tricalcium phosphate precursor precipitate. Particulate tricalcium phosphate compositions having an average crystal size of about 250 nm or less are provided. Compositions of the invention can be used as prosthetic implants and coatings for prosthetic implants.

Tricalcium phosphates, their composites, implants incorporating them, and methods for their production

The present invention relates to a biocompatible injectable filler composition comprising calcium phosphate particles having a porosity of about 10% to about 90%, a BET surface area of about 1 m/g to about 100 m/g, and a mean particle size of about 1 micron to about 30 microns, a thermoreversible hydrophilic gelling agent, a carrier comprising water and an optional persistence enhancer and/or volumizing agent, and methods of its use to restore tissue volume and/or to smooth out tissue defects as in soft tissue or deep tissue augmentation.

Injectable fillers for aesthetic medical enhancement and for therapeutic applications

Methods for synthesis of nanocrystalline apatites are presented, as well as a series of specific reaction parameters that can be adjusted to tailor, in specific ways, properties in the recovered product. Particulate apatite compositions having average crystal size of less than 150 nm are provided. Products also can have a surface area of at least 40 m/g and can be of high density. Hydroxyapatite material is investigated in particular detail. Compositions of the invention can be used as prosthetic implants and coatings for prosthetic implants.

Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production

The present disclosure provides compositions useful in regeneration of connective tissue, particularly bone. The compositions comprise a continuous matrix formed of a polypeptide crosslinked with a second polymer and further comprise particles of a porous, osteoconductive material dispersed in the continuous matrix. The composition can be provided in a dehydrated form. The disclosure further provides methods of preparing the composition in a clinically useful form, methods of using the composition in regenerating bone, and kits including the composition.

Continuous matrix with osteoconductive particles dispersed therein, method of forming thereof, and method of regenerating bone therewith

The invention provides a fusion device for use in spinal fusion procedures. The invention also provides systems and methods that include filling the fusion device with a cement composition.

Fusion device, systems and methods thereof

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Dover, MA, United States of America

Edward S Ahn