The University of British Columbia

University of Alberta

Inflazyme Pharmaceuticals Ltd.

Other

Edward Piers

Raymond John Andersen

Michel Roberge

John Coleman

Hassan Salari

David L Burgoyne

Yaping Shen

Debra Wallace

John M Langlands

Dilip De Silva

Christine Rogers

Fangming Kong

Theresa M Allen

Joseph H-l Chau

Robert Britton

Jasbinder Sanghera

Michael Roberge

James Nieman

Roberto Gs Berlinck

Daniel Leung

Teresa Allen

Joseph H L Chau

This invention relates to derivatives of hemiasterlin or Geodiamolide G having anti-mitotic activities and useful in treating cancer. These derivatives are represented by general formula I, wherein Y, n, R, R, R, R, R, R, R, R, R, and Rare as defined in the specification.

Biologically active peptides and compositions, their use

This invention provides analogs of hemiasterlin, methods of synthesis of the analogs and use of the analogs as cytotoxic and anti-mitotic agents.

Hemiasterlin analogs

Derivatives of hemiasterlin or Geodiamolide G having anti-mitotic activities and useful in treating cancer. These derivatives are represented by formula I wherein Y, n, R, R, R, R, R, R, R, R, and Rare as defined in the specification.

Steroid compounds having various oxygen substitution on the steroid nucleus are disclosed. A specific functionality present on many of the steroid compounds is oxygen substitution at both of positions 6 and 7. Thus, certain steroids have oxygen substitution at C6 and C7, and some have specific stereochemistries such as 6&#x3b1; and 7&#x3b2; oxygen substitution, and an alpha hydrogen at the 5 position in addition to having 6&#x3b1; and 7&#x3b2; oxygen substitution. Steroids having 3,4-epoxy functionality are also disclosed. In addition, steroids having C17 pyran and &#x3b4;-lactone functionality, with oxygen substitution at C6 and C7, or at C15, of the steroid nucleus, are disclosed.

6,7-Oxygenated steroids and uses related thereto

This invention relates to derivatives of hemiasterlin or Geodiamolide G having anti-mitotic activities and useful in treating cancer. These derivatives are represented by general formula I,

Steroid compounds having various oxygen substitution on the steroid nucleus are disclosed. A specific functionality present on many of the steroid compounds is oxygen substitution at both of positions 6 and 7. Thus, certain steroids have oxygen substitution at C6 and C7, and some have specific stereochemistries such as 6&agr; and 7&bgr; oxygen substitution, and an alpha hydrogen at the 5 position in addition to having 6&agr; and 7&bgr; oxygen substitution. Steroids having 3,4-epoxy functionality are also disclosed. In addition, steroids having C17 pyran and &dgr;-lactone functionality, with oxygen substitution at C6 and C7, or at C15, of the steroid nucleus, are disclosed.

6, 7-oxygenated steroids and uses related thereto

Novel granulatimide compounds and pharmaceutical formulations thereof are provided. Compounds of this invention have the general formula:

Granulatimide compounds and uses thereof

Steroid compounds having various oxygen substitution on the steroid nucleus are disclosed. A specific functionality present on many of the steroid compounds is oxygen substitution at both of positions 6 and 7. Thus, certain steroids have oxygen substitution at C6 and C7, and some have specific stereochemistries such as 6.alpha. and 7.beta. oxygen substitution, and an alpha hydrogen at the 5 position in addition to having 6.alpha. and 7.beta. oxygen substitution. Steroids having 3,4-epoxy functionality are also disclosed. In addition, steroids having C17 pyran and .delta.-lactone functionality, with oxygen substitution at C6 and C7, or at C15, of the steroid nucleus, are disclosed.

6,7-oxygenated steroids and uses related thereto

Growing community of inventors

Vancouver, Canada

Edward Piers