Aeris Therapeutics, Inc.

The Brigham and Women's Hospital, Inc.

Bistech, Inc.

Other

Boston University

Pulmonx Corporation

Edward P Ingenito

Larry W Tsai

Alexander Schwarz

James A Krom

Steven James Mentzer

Bela Suki

Kenneth R Lutchen

Scott J Swanson

John J Reilly, Jr

One aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant nucleophilic groups and a crosslinker comprising at least two pendant electrophilic groups. Another aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant electrophilic groups and a crosslinker comprising at least two pendant nucleophilic groups. Yet another aspect of the invention relates to a method for reducing lung volume in a patient comprising the step of administering a hydrogel composition as described herein. Further, hydrogels of the invention may be used to achieve pleurodesis, seal brochopleural fistulas, seal an air leak in a lung, achieve hemostasis, tissue sealing (e.g., blood vessels, internal organs), or any combination thereof. In certain embodiments, the compositions and methods described herein are intended for use in the treatment of patients with emphysema.

Lung volume reduction therapy using crosslinked non-natural polymers

One aspect of the present invention relates to bronchoscopic lung volume reduction using solutions of biopolymers that can be polymerized in situ with a crosslinker and a polymeric additive which accelerates the cross-linking reaction. In certain embodiments, the biopolymer solutions can be in the form of a foam or gel. The biopolymer compositions disclosed herein may also be used for indications other than lung volume reduction, such as sealing fistulas or performing emergency tamponade of vessels.

Lung volume reduction therapy using crosslinked biopolymers

One aspect of the invention relates to a hydrogel comprising a polymer comprising a plurality of pendent hydroxyl groups, a crosslinker, and a sclerosing agent. Another aspect of the invention relates to a method for reducing lung volume in a patient comprising the steps of advancing into a region of a patient's lung via said patient's trachea a multi-lumen catheter lumen through a bronchoscope; and co-administering, through the multi-lumen catheter, a first mixture comprising a first amount of a polymer containing a plurality of pendent hydroxyl groups; a second mixture comprising a second amount of a crosslinker; and a third mixture comprising a third amount of a sclerosing agent; thereby forming a hydrogel in said region. In certain embodiments, the compositions and methods described herein are intended for use in the treatment of patients with emphysema of the lung.

Polymer systems for lung volume reduction therapy

A hand-held apparatus that delivers pressurized breathing gas to the airway of a patient, thereby creating positive end expiratory pressure (PEEP) and reducing respiratory muscle fatigue. The apparatus includes a deformable reservoir, a breathing interface, and a pressure relief valve. The apparatus may include a means for creating fluid communication between the deformable reservoir and a source of pressurized breathing gas. The apparatus may also include an adjuster that allows a user to vary the pressure of the breathing gas contained in the deformable reservoir.

Respiratory assistance apparatus and method

The invention includes a method for performing non-surgical lung volume reduction in a patient by applying an amount of energy with a catheter to a diseased alveolar region of the lung of a patient having emphysema, wherein the amount of energy is sufficient to damage the epithelial cells and the epithelial barrier within the diseased alveolar region of the lung and collapse at least a portion of said region thereby reducing the lung volume, and wherein the energy comprises thermal energy, electrical energy, and ultrasonic energy.

Compositions and methods for reducing lung volume

Devices, compositions, and methods for achieving non-surgical lung volume reduction (e.g., bronchoscopic lung volume reduction (BLVR)) are described. BLVR can be carried out by collapsing a region of the lung, adhering one portion of the collapsed region to another, and promoting fibrosis in or around the adherent tissue.

Tissue volume reduction

A system and method for ventilating a lung in a living being by varying the peak inspiratory pressure. The peak inspiratory pressure may deviate about a mean that is chosen to correspond with a knee in a pressure-volume curve of the lung.

Variable peak pressure ventilation method and system

The present invention is directed to a prosthetic device that can be implanted in the pleural cavity of patients undergoing lung volume reduction surgery. The device is designed so that its volume can be adjusted by externally adding or removing gas without the need for additional surgical intervention.

Growing community of inventors

Kingston, MA, United States of America

Edward P Ingenito