Molecular Medicine Research Institute

Genentech, Inc.

Connetics Corporation

Edward P Amento

Chrishan S Samuel

Christian S Samuel

Eugene A Bauer

L Steven Beck

The present invention relates to the discovery that relaxin is associated with the development or maturation of body tissues. Knockouts of the gene encoding relaxin result in various abnormalities in the development of various tissues. The present invention provides methods of modulating apoptosis by administering a relaxin agonist or antagonist to a subject.

Methods of modulating apoptosis by administration of relaxin agonists or antagonists

Depression, particularly disease- and medical treatment-related depression, and especially postpartum depression, is treated by the administration of a therapeutically effective amount of relaxin. A treatment regimen and dosage form for gradual withdrawal from relaxin therapy is also disclosed.

Method of treatment for depression

A method of predisposing a mammal to accelerated tissue repair is provided. This method comprises systemically administering to the mammal, prior to its exposure to tissue damage, an effective amount of TGF-.beta.. Preferably, the TGF-.beta. is administered no more than about 24 hours prior to exposure to tissue damage.

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Portola Valley, CA, United States of America

Edward P Amento