Biora Therapeutics, Inc.

Progenity, Inc.

Shimizu, Jeffrey A.

Wahl, Christopher Loren

Bunce, Christopher Ian

Mudge, Edward

Jones, Mitchell Lawrence

Stevens, Nia Eleri

Salt, Nicholas Mark

Abercombie, Stuart Robert

Muller, Nathan John

Niknia, Iman

Nguyen, Tuyen

Drlik, Mark Sasha

Jones, Ryan Elliott

Edward Mudge

Mitchell Lawrence Jones

Christopher Loren Wahl

Mark Sasha Drlik

Nathan John Muller

Tuyen Nguyen

Jeffrey A Shimizu

Nelson Quintana

Iman Niknia

Nicholas Mark Salt

Nia Eleri Stevens

Stuart Robert Abercrombie

Christopher Ian Bunce

Kevin Howe

Pejman Rahimian

Ryan Elliott Jones

Kevin David Howe

Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Ingestible device for delivery of therapeutic agent to the gastrointestinal tract

A method of treating a disease or condition in a subject in need thereof is disclosed. The method comprising: trans-epithelially administering a dispensable substance to the gastrointestinal (GI) tract of the subject by orally administering an ingestible device comprising the dispensable substance to the subject. The ingestible device is configured for trans-epithelial delivery of the dispensable substance to the GI tract of the subject and the dispensable substance comprises a pharmaceutical formulation comprising a therapeutically effective amount of a glucagon receptor agonist or a glucagon-like peptide-1 (GLP-1) receptor agonist. The ingestible device releases the dispensable substance as at least one jet to a desired location of the GI tract of the subject.

An ingestible device, includes a storage reservoir configured to store a dispensable substance and a pressurized chamber configured so that, when a restraining force is removed from the pressurized chamber, the dispensable substance exits the ingestible device via openings in the ingestible device.

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Cambridgeshire, United Kingdom

Edward Mudge