Marquette University

Uwm Research Foundation, Inc.

Wisconsin Alumni Research Foundation

Edward Merle Johnson, Ii

James M Cook

David A Baker

Wenyuan Yin

Ranjit Singh Verma

The present invention provides cysteine and cystine bioisosteres for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing such bioisosteres and methods of using the bioisosteres for treatment of schizophrenia and drug addiction.

Cysteine and cystine bioisosteres to treat schizophrenia and reduce drug cravings

The present invention discloses cysteine prodrugs having the general formula: cystine dimers of the cysteine prodrugs having the general formula: protected cysteine analogs having the general formula: and dimers of the protected cysteine analogs having the general formula:  The invention further encompasses pharmaceutical compositions containing the disclosed prodrugs, dimers, and analogs, and methods of using such compounds for treatment of schizophrenia and drug addiction.

Cysteine and cystine prodrugs to treat schizophrenia and reduce drug cravings

The present invention provides cysteine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction.

Cysteine prodrugs to treat schizophrenia and drug addiction

The present invention provides cysteine and cystine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction. Exemplary prodrugs include the cysteine compound having the formula as well as cystine dimers thereof.

Growing community of inventors

Glendale, WI, United States of America

Edward Merle Johnson, Ii