Warner-Lambert Company

British Technology Group Limited

National Research Development Corporation

British Tech. Group

Edward M Fielden

Gerald E Adams

Ian J Stratford

Howard D Showalter

Matthew A Naylor

Vladimir Genukh Beylin

Anthony Denver Sercel

Terence C Jenkins

Vladimir G Beylin

Anthony D Sercel

Chiral compounds useful as radiosensitizers or chemosensitizers having the formula ##STR1## wherein X is halogen or ##STR2## intermediates used to prepare these compounds, and a novel process to prepare these compounds are described.

Chiral [[(2-bromoethyl)-amino]methyl]-2-nitro-1H-imidazol-1-ethanol and

Process for preparing chiral

A compound for treating a patient having a solid tumor in which it is known or suspected that hypoxic cells are present, which is a compound of formula (A): ##STR1## wherein X represents a nitro-substituted aromatic or hetero-aromatic group with a one-electron reduction potential at pH 7 of from -250 to -500 mV; each of R'.sub.1 to R'.sub.5 independently represents hydrogen or an alkyl, hydroxyalkyl, aryl, aralkyl or alkaryl group; m is 0 or 1; n is 1 or 2; and Z' represents a leaving group which has the potential for expulsion via an intramolecular cyclization reaction; or a physiologically acceptable acid addition salt thereof.

Nitro-substituted aromatic or hetero-aromatic compounds for use in

Growing community of inventors

Blewbury, United Kingdom

Edward M Fielden