Tbl Development Corporation

Other

The Brigham and Women's Hospital, Inc.

Nps Pharmaceuticals, Inc.

The General Hospital Corporation

Marical, Inc.

Lermer Packaging Corp.

Spray-all, Inc.

Edward M Brown

Edward J Towns

William M Lester

Steven C Hebert

James E Garrett

David T Scadden

Mark C Poznansky

Marlies Betka

H William Harris, Jr

Jacqueline Nearing

David R Russell

Matthias A Hediger

Steven Harold Jury

H William Harris

Edward B Chamberlin

Neil Hugh Downing

Ivona T Olszak

Ji-Bin Peng

Timothy Linley

John Daniel Proctor

Bradford C Van Wagenen

Manuel F Balandrin

Eric G Del Mar

Edward F Nemeth

Forrest H Fuller

Ruben A Diaz

David I Soybel

Stephen J Quinn

Mei Bai

Joseph Frank Spano

Leonard Dykstra

This invention relates to methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention relates to methods and compositions for modulating movement of CaR receptor expressing cells of hematopoietic, neural, epithelial, endothelial, or mesenchymal origin, in a specific site in a subject. The foregoing are useful, inter alia, in the treatment of conditions characterized by a need to modulate migratory-cell movement associated with specific sites in a subject. Specific sites include sites of inflammation and modulation of migratory-cell movement is movement away from an agent source, or repulsion. The invention also relates to methods for manipulating hematopoeitic progenitor cells and related products. In particular the invention includes methods and products for using CaR receptor-related compositions to enhance mobilization of hematopoietic progenitor cells, to improve the efficiency of targeting cells to the bone marrow, and/or to modulate hematopoietic progenitor cell function.

CaR receptor as a mediator of migratory cell chemotaxis and/or chemokinesis

Methods of altering transmembrane calcium transport by altering expression of a calcium-transport protein are described.

Methods of altering calcium transport

The present invention relates to methods of imprinting fish in freshwater with at least one odorant for the fish and causing the imprinted fish to react to the odorant in seawater, wherein the fish are maintained in freshwater prior to transfer to seawater, The method includes: adding at least one Polyvalent Cation Sensing Receptor (PVCR) modulator to the freshwater in an amount sufficient to modulate expression and/or sensitivity of at least one PVCR, the PVCR modulator being one which alters olfactory sensing of the fish to the odorant; adding feed for fish consumption to the freshwater, the feed containing the odorant and an amount of NaCl sufficient to contribute to a significantly increased level of the PVCR modulator in serum of the fish upon consumption of the feed, whereby the fish are imprinted with the odorant; transferring the imprinted fish to seawater; and providing a source of said odorant in the seawater to which the imprinted fish are transferred, thereby causing the imprinted fish to react to said odorant. The present invention also includes methods of homing or attracting fish, as well as methods for repelling fish by modulating the expression and/or sensitivity of the PVCR in the olfactory apparatus of the fish.

Methods for growing and imprinting fish using an odorant

Polycation-sensing receptors present in aquatic species and methods of regulating polycation-sensing receptor-mediated functions in aquatic species are described.

Polycation-sensing receptor in aquatic species and methods of use thereof

The present invention relates to methods of imprinting fish in freshwater with at least one odorant for the fish and causing the imprinted fish to react to the odorant in seawater, wherein the fish are maintained in freshwater prior to transfer to seawater. The method includes: adding at least one Polyvalent Cation Sensing Receptor (PVCR) modulator to the freshwater in an amount sufficient to modulate expression and/or sensitivity of at least one PVCR, the PVCR modulator being one which alters olfactory sensing of the fish to the odorant; adding feed for fish consumption to the freshwater, the feed containing the odorant and an amount of NaCl sufficient to contribute to a significantly increased level of the PVCR modulator in serum of the fish upon consumption of the feed, whereby the fish are imprinted with the odorant; transferring the imprinted fish to seawater; and providing a source of said odorant in the seawater to which the imprinted fish are transferred, thereby causing the imprinted fish to react to said odorant. The present invention also includes methods of homing or attracting fish, as well as methods for repelling fish by modulating the expression and/or sensitivity of the PVCR in the olfactory apparatus of the fish.

Nucleic-acid and amino-acid sequences correspond to a calcium-transport protein regulating the movement of calcium across cell membranes.

Compositions corresponding to a calcium transporter and methods of making and using same

Polycation-sensing receptor in aquatic species and methods of use

The present invention is directed to methods for treating cancer patients by administering ligands that bind with specificity to the calcium-sensing receptor. In addition, the invention is directed to methods for detecting transformed cells by determining the number of calcium-sensing receptors present.

Human calcium-sensing receptor in the detection and treatment of cancer

The present invention is directed to an avian calcium-sensing receptor and to DNA sequences which encode the receptor. In addition, the invention is directed to methods and compositions which serve to modulate the serum concentration of calcium in humans and animals.

Avian extracellular calcium-sensing receptor

The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca.sup.2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.

Calcium receptor-active molecules

Method of screening calcium receptor-active molecules

The present invention features calcium receptor polypeptides and fragments thereof. Uses of a calcium receptor polypeptide include providing a polypeptide having the activity of a calcium receptor polypeptide. Calcium receptor polypeptide fragments can be used, for example, to generate antibodies to a calcium receptor polypeptide.

An improved container and closure therefore particularly adapted for use in storing pressurized liquid contents, such as carbonated beverages. As contrasted with conventional crown seals which employ a sealing gasket, the closure effects a sealing action between corresponding frustoconical sealing surfaces on the container finish and an inner surface of the cap, thus eliminating the need for a gasket. The closure includes a tamper indicating means at a lower peripheral edge thereof which is damaged upon engagement with an opening tool or other object.

Container and closure therefore having conical sealing surfaces

Growing community of inventors

Livingston, NJ, United States of America

Edward M Brown