Pacesetter, Inc.

St. Jude Medical, Cardiology Division, Inc.

Covidien LP

Nellcor Puritan Bennett Incorporated

St. Jude Medical Ab

Tc1 LLC

Edward Karst

Gene A Bornzin

Wenbo Hou

Taraneh Ghaffari Farazi

Stuart Rosenberg

Fujian Qu

Yelena Nabutovsky

Rupinder Bharmi

Allen J Keel

Brian Jeffrey Wenzel

Kritika Gupta

Clark Raymond Baker, Jr

Riddhi Shah

Alexander Kent

Xiaoyi Min

Timothy A Fayram

Kyungmoo Ryu

Carine Hoarau

Jong Gill

John W Poore

Laurence S Sloman

Zoltan Somogyi

Didier Theret

Ryan Rooke

Richard Samade

Michael E Benser

Lisa P Weinberg

Tomas Svensson

Bruce A Morley

Timothy Pflugh

Benjamin Coppola

Xing Pei

Kjell Noren

Sven-Erik Hedberg

Yongjian Wu

Charles E Porges

Hoda Razavi

Jennifer Rhude

Joseph Douglas Vandine

Rohan More

Kwangdeok Lee

Craig A Hewitt

Paul A Levine

Euljoon Park

Gabriel A Mouchawar

Rahul Kumar Agarwal

Eric Steven Fain

Kjell Norén

Edith Merle Arnold

Nirav Dalal

Caroline D Jordan

Larry Sloman

Risshi Shah

The present disclosure provides a grip sensor for quantifying pain experienced by a patient during spinal cord stimulation (SCS). The grip sensor includes an electronics enclosure, an annular outer shell substantially surrounding the electronics enclosure and sized to be held by the patient, a pressure sensor embedded in the outer shell and communicatively coupled to the electronics enclosure, the pressure sensor configured to measure a grip strength of the patient as SCS is applied to the patient, and a plurality of galvanic skin response sensors communicatively coupled to the electronics enclosure and configured to measure an electrical impedance of the skin of the patient as SCS is applied to the patient.

Systems and methods for determining spinal cord stimulation parameters based on patient feedback

An apparatus and method for characterizing a region of interest (ROI) including measuring position and orientation data within the ROI; and generating a geometric data set to include one or more of: length, bifurcation location, angle and curvature characteristics of the ROI. Also, sequentially taking an image of a tool within the ROI; comparing tool dimensions with ROI dimensions; and estimating diameter, length, take-off angle, and/or tortuosity characteristics based on the comparisons.

Vascular branch characterization

A system for supplying power transcutaneously to an implantable device implanted within a subject is provided. The system includes an external connector including one of a microneedle array and a microwire holder. The system further includes a power cable electrically coupled to the external connector and configured to supply power to the one of the microneedle array and the microwire holder, and an internal connector configured to be implanted within the subject and electrically coupled to the implantable device, the internal connector including the other of the microneedle array and the microwire holder. The microneedle array includes a plurality of electrically conductive microneedles, the microwire holder includes a plurality of electrical contacts, and the microwire holder is configured to engage the microneedle array such that the plurality of electrically conductive microneedles extend through the skin of the subject and electrically couple to the plurality of electrical contacts.

Systems and methods for transcutaneous power transfer using microneedles

Example electronic devices, including but not limited to implantable medical devices, and methods employing dynamic announcing for creation of wireless communication connections are disclosed herein. In an example, an electronic device includes a wireless communication interface to transmit announcement signals for creating a wireless communication connection with the external device. The electronic device also includes a sensor to detect a characteristic of an environment external to the electronic device, and a control circuit including an announcement timing control module to dynamically control timing of the announcement signals based on the detected characteristic.

Dynamic announcing for creation of wireless communication connections

The present disclosure provides systems and methods for integrating cardiac resynchronization therapy (CRT) and temporary induced dyssynchrony (TID) therapy. An implantable cardiac device includes one or more pulse generators coupled to a plurality of electrodes, and a controller communicatively coupled to the one or more pulse generators and configured to cause the one or more pulse generators to apply a combination of CRT and TID therapy to a patient's heart via the plurality of electrodes in accordance with at least one protocol.

Systems and methods for integrating temporary induced dyssynchrony therapy with cardiac resynchronization therapy

The present disclosure provides a spinal cord stimulation (SCS) system. The system includes at least one SCS lead including a lead body, at least one distal electrode located at a distal end of the lead body, the at least one distal electrode configured to apply electrical stimulation to a stimulation target of a patient, and a pain reduction assembly coupled to the lead body and configured to reduce post-operation pain at an incision site associated with implantation of the at least one SCS lead. The system further includes a pulse generator coupled to the at least one SCS lead and configured to control electrical stimulation delivered to the patient via the at least one SCS lead.

Systems and methods for reducing pain during spinal cord stimulation trial

Described herein are methods, devices, and systems for treating human anemia. The methods, devices, and systems generally include monitoring a patient's hemoglobin level and at least one of autonomic balance and inflammatory state to determine the etiology of the anemic state, modulating at least one of a sympathetic or parasympathetic nerve based on the cause of the anemia, monitoring for changes in the patient's cardiac activity and state of inflammation, and hemoglobin level. An external neurostimulation system is describes, and well as a chronic implantable system. A method for treating a patient for anemia in conjunction with a renal denervation ablation catheter is also disclosed.

Erythropoeitin production by electrical stimulation

The present disclosure provides systems and methods for providing temporary induced dyssynchrony (TID) therapy to patients with atrial tachycardia. An implantable cardiac device includes a pulse generator coupled to a plurality of electrodes, and a controller communicatively coupled to the pulse generator and configured to cause the pulse generator to apply TID therapy to a patient's heart via the plurality of electrodes, determine that the patient's heart is experiencing atrial tachycardia, and adjust at least one parameter of the TID therapy based on the determination.

Systems and methods for providing temporary induced dyssynchrony therapy to patients with atrial tachycardia

Systems and methods are provided for determining a system response for a neuronal region of interest (ROI). The method comprises positioning an electrode proximate to the neuronal ROI. The electrode is electrically coupled to a neurostimulation (NS) system. The system delivers, from the NS system, a stimulation waveform from the electrode based on NS parameters. The system further programs one or more processors for: measuring an evoked potential waveform resulting from the stimulation waveform; comparing at least one excitation pulse within the stimulation waveform to the evoked potential waveform to obtain a candidate response function; repeating the delivering, measuring and comparing operations to obtain a collection of candidate response functions; and identifying a neuronal system response for the neuronal ROI based on the collection of candidate response functions.

System and method for determining neuronal system response

The present disclosure provides systems and methods for correlating measurement in neurostimulation systems. A neurostimulation system includes a first sensor configured to acquire movement measurements for a subject, a second sensor configured to acquire neural measurements for the subject, and a computing device communicatively coupled to the first and second sensors. The computing device is configured to receive a movement signal from the first sensor, and receive a neural signal from the second sensor, wherein one of the movement signal and the neural signal is a trigger signal and the other of the movement signal and the neural signal is a signal of interest. The computing device is further configured to detect at least one trigger event in the trigger signal, and use the signal of interest based on the at least one trigger event.

Systems and methods for correlating measurements in neurostimulation systems

A renal denervation system includes an ablation catheter and an inflation balloon. The renal denervation catheter is insertable into a renal artery to perform a renal denervation procedure. The inflation balloon is inflatable within the renal artery, wherein one of a blood pressure condition in the renal artery resulting from operation of the inflation balloon and a performance characteristic of the inflation balloon indicates efficacy of the renal denervation procedure.

Feedback systems and methods for renal denervation utilizing balloon catheter

Provided herein are implantable systems, and methods for use therewith, for monitoring a patient's arterial blood pressure while a patient's heart is being paced. A signal (e.g., PPG or IPG signal) indicative of changes in arterial blood volume remote from the patient's heart is obtained using a sensor or electrodes that are implanted remote from the patient's heart. One or more metrics indicative of pulse arrival time (PAT) are determined, where each metric can be determined by determining a time from a paced cardiac event to one or more predetermined features of the signal indicative of changes in arterial blood volume. Based on at the metric(s) indicative of PAT, arterial blood pressure is estimated, which can include determining values indicative of systolic blood pressure, diastolic blood pressure, pulse pressure and/or mean arterial blood pressure, and/or changes in such values.

Arterial blood pressure monitoring devices, systems and methods for use while pacing

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Los Angeles, CA, United States of America

Edward Karst