Iris International, Inc.

Iris Molecular Diagnostics, Inc.

Edward Jablonski

Thomas H Adams

Robert E Klem

Carl Hulle

Mark J Sarno

Russ Saunders

The present disclosure relates to compositions, methods, and kits for the rapid detection, separation and/or isolation of microorganisms. Specifically, the disclosure relates to compositions, methods, and kits for using vancomycin&#x2014;PVA backbone complexes to capture and/or concentrate microorganisms in an aqueous sample, such as gram positive and/or gram negative bacteria in solution.

Conjugation of multiple vancomycin molecules on a polyvinyl alcohol backbone for the capture of microorganisms

The present disclosure relates to compositions, methods, and kits for the detection, separation and/or isolation of microorganisms. Specifically, the disclosure relates to compositions, methods, and kits for using polylysine-coated particles to capture microorganisms such as bacteria.

Method of capturing bacteria on polylysine-coated microspheres

The present invention provides novel binding pair compositions of defined and limited stability comprising nucleic acid detection markers useful for the homogeneous, sensitive detection of analytes. Also provided are methods for the sensitive homogenous detection of analytes, particularly analytes of clinical relevance. Kits for preparing binding pairs of the invention and for performing the methods of the invention are also provided.

Homogeneous analyte detection

The present invention relates to methods, compositions and kits for affinity isolation, affinity purification and affinity assay based on microbubbles coated with an affinity molecule. Particularly, the invention provides protein microbubbles coated with an affinity molecule. In addition, the invention provides glass microbubbles coated with an affinity molecule. Methods of using the microbubbles of the invention for isolating analytes and cells are specifically provided.

Microbubbles for affinity separation

The present invention provides novel binding pair compositions of defined and limited stability comprising nucleic acid detection markers useful for the homogeneous, sensitive detection of analytes. Also provided are methods for the sensitive homogeneous detection of analytes, particularly analytes of clinical relevance. Kits for preparing binding pairs of the invention and for performing the methods of the invention are also provided.

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Escondido, CA, United States of America

Edward Jablonski