Merck + Co., Inc.

Other

Edward J J Grabowski

Richard D Tillyer

Feng Xu

Robert D Larsen

Paul J Reider

Ian W Davies

Dalian Zhao

Cheng Yi Chen

Robert A Reamer

Lisa F Frey

Paul O'Shea

Xin Wang

Mandana Asgharnejad

Anthony On-Ping King

Stephane G Ouellet

Jose M Vega

The instant invention provides methods and pharmaceutical compositions for inhibiting HMG-CoA reductase, as well as for treating and/or reducing the risk for diseases and conditions affected by inhibition of HMG-CoA reductase, comprising orally administering a therapeutically effective amount of a compound selected from a dihydroxy open acid statin and a pharmaceutically acceptable salt or ester thereof in a delayed-release pharmaceutical dosage form to a patient in need of such treatment wherein substantial release of the compound from the dosage form is delayed until after passage of the dosage form through the stomach.

Dihydroxy open-acid and salts of HMG-CoA reductase inhibitors

This invention encompasses a novel process for synthesizing compounds represented by formula A:

Synthesis of methylthiophenyl hydroxyketones

A rearrangement process for the preparation of a 6,5,5-tricyclic, a 6,6,5-tricyclic and 6,5,5,7-tetracyclic ring system is disclosed.

Rearrangement process and tricyclic and tetracyclic compounds

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Westfield, NJ, United States of America

Edward J J Grabowski