Teva Women's Health, Inc.

Enhance Pharmaceuticals, Inc.

Edward J Gabrielski

Tahseen A Chowdhury

Christopher H Baker

John F Cline

Angela Reid-Haqq

Michelle McKenna

The present invention relates to a method of attaching a handle to a solid oral dosage form by use of high frequency mechanical vibrations. The present invention also relates to a method of attaching a handle to a solid oral dosage form, the method comprising: (a) placing a handle in contact with a solid oral dosage form, wherein an area of contact between the handle and the solid oral dosage form forms a joint interface; (b) applying high frequency mechanical vibrations to the joint interface until the solid oral dosage form at the joint interface reaches a molten state; and (c) cooling the joint interface in a molten state to allow solidification, thereby attaching the handle to the solid oral dosage form.

Attachment of a handle to a solid oral dosage form

A method for attaching a handle to a tablet to form a lollipop utilizes a specific work holder. The work holder has a tooling pallet with a plurality of openings going from a top surface to a bottom surface. A bullet and a spring are located in each opening and held in place by a plate that slides through a groove in the bottom surface of the tooling pallet to block the openings in the bottom surface. Each spring is positioned between a bullet and the plate. A tablet is placed in a cavity of each bullet and a handle is placed in contact with each tablet. High frequency mechanical vibrations, such as ultrasonic vibrations, are applied to a joint interface between each tablet and bullet until the joint interface reaches a molten state. The joint interfaces are then allowed to cool, thereby attaching a handle to each tablet and forming a lollipop.

Method for making a lollipop

Thermoset polymer controlled release devices are produced by an injection molding of two or more polymers in a mold to produce a core surrounded by a sheath. The polymers may be injected sequentially or simultaneously.

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Bound Brook, NJ, United States of America

Edward J Gabrielski