Colgate Palmolive Company

Edward J Duff

Kenneth Tomlinson

Ronald S Schreiber

The process of preparing analytically pure fluorapatite comprising reacting dicalcium phosphate dihydrate with hydrogen fluoride in aqueous solution, at a pH of from about 5 to about 8, at from about room temperature for about 7 days to about 100.degree. C. for about 2 days, the amount of fluoride ion being from about stoichiometric to about 1.1 times the stoichiometric amount of dicalcium phosphate dihydrate whereby solid analytically pure fluorapatite is formed.

Process for preparing fluorapatite

Process for preparing dicalcium phosphate dihydrate with displacement 0.1 - 5% of the calcium by divalent metal ion.

Process for preparing dicalcium phosphate dihydrate having a portion of

A process of supplying fluoride to teeth comprising applying to the teeth a source of fluoride ions and an orthophosphoric acid solution having a pH of about 3-4, then neutralizing the pH to about 7 with an aqueous neutralizing solution containing calcium ions and phosphate ions, wherein there is present about a stoichiometric amount of the phosphate ions relative to the calcium ions, the neutralizing solution having a pH of about 7.

Process of preparing materials having calcium and phosphate components

Novel bis long chain (C.sub.8 - C.sub.18) amine monofluorophosphates, particularly useful as substantive, slow release fluoride agents for anti-caries prophylaxis; the process of preparing said amine monofluorophosphates; and compositions containing an effective amount of said fluoride agent admixed with a pharmaceutical carrier, more particularly an oral composition.

Amine monofluorophosphates in dentifrices

Dental preparations containing materials having calcium and phosphate components are described. Such materials are typically fluorapatite, fluorohydroxyapatite, hydroxyapatite prepared by alternately changing the pH from about 7 to about 4 to about 7 several times, including such materials which have incorporated therein ions such as monofluorophosphate and carbonate or divalent ions such as zinc or fluoranions of a metal such as zinc, e.g. ZnF.sub.4.sup.-2.

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Sandbach, United Kingdom

Edward J Duff