Corvia Medical, Inc.

Dc Devices, Inc.

Mitralign, Inc.

C. R. Bard, Inc.

Volcano Corporation

Lightlab Imaging, Inc.

Massachusetts Institute of Technology

Edwards Lifesciences Corporation

Custom Medical Concepts, Inc.

Edward I McNamara

Hiroatsu Sugimoto

Stephen Forcucci

Matthew J Finch

David Stephen Celermajer

Michael W Sutherland

Aaron M Call

Paul A Spence

Joseph P Lane

Donald S Baim

Jason Robinson

Mark A Maguire

Steven D Cahalane

Paul A Magnin

Christopher L Petersen

Eric Arthur Swanson

Russell W Bowden

Christopher Lee

Richard J Morrill

Christopher J Magnin

Rodney J Solomon

Joseph M Schmitt

Edward L Sinofsky

Carol A Devellian

Ronald B Lamport

Kate E Cutuli

John Mitzel

Kenneth J Daignault, Jr

Michael F Weiser

Harith Rajagopalan

James G Fujimoto

Michael Atlas

Megan E Holmes

Mark Brezinski

Stephen A Boppart

Gary L Boseck

Paul T Modoono

David L Kelly

James E Heavner

Grigory Kizelshteyn

Dennis M Goodine

Kate E Traynor

Joseph A Meranda

Ron B Lamport

Constantinos Pitris

Xingde Li

A method and devices for relieving pressure in the left atrium of a patient's heart is disclosed. The method includes using an ablative catheter in a minimally invasive procedure to prepare an opening from the coronary sinus into a left atrium of the patient's heart. Once the opening is prepared, the opening may be enlarged by a technique such as expanding a balloon within the opening. A stent is then placed within the coronary sinus of the patient, with a transverse portion expanding within the opening, allowing blood to flow from the left atrium to the coronary sinus and then to the right atrium. Pressure within the left atrium is thus relieved.

Devices and methods for coronary sinus pressure relief

Systems, devices and methods for securing tissue including the annulus of a mitral valve. The systems, devices and methods may employ catheter based techniques and devices to plicate tissue and perform an annuloplasty.

Tissue anchors, systems and methods, and devices

The present disclosure relates to a method and a device for treating heart failure by normalizing elevated blood pressure in the left and right atria of a heart of a mammal. The present disclosure includes methods for creating and maintaining an opening in the atrial septum. Tools for making an opening and enlarging the opening are also disclosed. Use of the techniques and tools described herein prolongs the patency of an intra-atrial pressure relief opening.

Apparatus and methods to create and maintain an intra-atrial pressure relief opening

Several unique intra-cardiac pressure devices, placement catheters, methods of placement and methods of treating heart failure are presented. The intra-cardiac pressure devices presented allow sufficient flow from the left atrium to the right atrium to enable the relief of elevated left atrial pressure and resulting patient symptoms. The intra-cardiac pressure devices are made of a non-braided material.

Intra-atrial implants made of non-braided material

The present teachings provide a device to change the pressure in a chamber of a heart and methods of making and using thereof. One aspect of the present teachings provides a device comprising a frame (for example, a metallic frame) and a scaffold. The frame of the device has a distal flange portion, a shunt portion, and a proximal flange portion. The distal and proximal flange portions can align with the shunt portion and form an elongated first profile. At least one of the distal and proximal flange portions can bend radially away from the shunt portion to form a flange like profile. The scaffold includes one or more than covering layers and encloses parts of the frame or the entire frame. The covering layer provides a barrier between the biological matter and the frame of the device. The scaffold is designed to control and direct tissue growth, for example, by stimulating an irritation response and inducing cell proliferation around the retention flange and/or discouraging cell proliferation inside the shunt portion.

Devices and methods for treating heart failure

The present teachings provide a device to close a ductus arteriosus percutaneously. One aspect of the present teachings provides a device comprising at least one flange portion configured to be positioned against a vascular wall outside one end of a ductus arteriosus, and a body portion configured to be positioned inside the ductus arteriosus. The body portion of the device has a length adjustable in order for the device to fit inside patients with various ductus arteriosus lengths. The at least one flange portion of the device has pivotability in order for at least one flange to deflect from the longitudinal axis of the body portion so that the deployed device can be positioned at a treatment site allowing the discs to sit flat against the vascular tissue to promote closure while avoiding disruption of flow within the pulmonary artery and aorta or applying excess pressure to the surrounding vascular tissue. The body portion of the device could also at least partially block the ductus arteriosus, and thereby reduce or obstruct blood flow through the ductus arteriosus. The device includes a delivery profile and a deployment profile. Another aspect of the present teachings provides methods of using a device of the present teachings.

Devices and methods for treating patent ductus arteriosus

A device for implanting into an atrial septum of a patient. In some embodiments, the device has a core region to be disposed in an opening in the atrial septum; a distal retention region adapted to engage tissue on a left atrial side of the septal wall; a proximal retention region adapted to engage tissue on a right atrial side of the septal wall; and a retrieval region comprising a plurality of retrieval members, each retrieval member comprising a connector at a proximal end, the connector being adapted to connect to a delivery system. The device has a delivery configuration and a deployed configuration, the core region, distal retention region and proximal retention region each having a smaller diameter in the delivery configuration than in the deployed configuration, the retrieval member connectors being disposed proximal to and radially outward from the opening in the deployed configuration.

The present disclosure relates to devices and methods for implanting a prosthesis into a heart of a mammal, such as a person. The disclosure includes a prosthesis that acts as a pressure vent between the left and right atria of the heart. The disclosure also includes a mounting tool for mounting the prosthesis onto a loading tool, the loading tool useful for loading the prosthesis onto a device for delivering the prosthesis into the patient's heart. Control devices and methods for using these devices are also disclosed. The intracardiac pressure vents disclosed allow sufficient flow from the left atrium to the right atrium to relieve elevated left atrial pressure and resulting patient symptoms. The devices also limit the amount of flow from the right atrium to the left atrium to minimize the potential for thrombi or other embolic material from entering arterial circulation.

Methods for deploying a prosthesis

The present disclosure relates to improved capabilities for stabilizing and regulating atrial pressure with a shunt in the atrial septum or a stent in the coronary sinus. The disclosure also includes sensing, monitoring, drug therapy and control capabilities to provide improved treatment of patients with heart disease and other cardiac related conditions.

Atrial pressure regulation with control, sensing, monitoring and therapy delivery

The invention is a septal implant that can accommodate variable thicknesses of the patient's atrial septum as well the variable thicknesses of septums across a population. The invention is able to accomplish this result by having flexible annular flanges that define a gap into which the septum fits. Due to the flexible nature of the annular flanges, the gap is adjustable.

Intra-atrial implants having variable thicknesses to accommodate variable thickness in septum

Devices and methods for treating heart disease by normalizing elevated blood pressure in the left and right atria of a heart of a mammal are disclosed. Devices may include an adjustable hydraulic diameter and/or a removable and/or replaceable shunt portion. Devices may include absorbable materials, the absorption of which directly or indirectly causes alterations of the fluid flow capacities the devices.

Methods, systems, and devices for resizable intra-atrial shunts

Several unique intra-cardiac pressure vents, placement catheters, methods of placement and methods of treating heart failure are presented. The intra-cardiac pressure vents presented remain partially open under normal intra-cardiac pressures to allow sufficient flow from the left atrium to the right atrium to enable the relief of elevated left atrial pressure and resulting patient symptoms, and also limit the amount of flow from the right atrium to the left atrium by closing when the pressure in the right atrium exceeds the pressure in the left atrium by a predetermined amount.

Devices, systems, and methods to treat heart failure having an improved flow-control mechanism

Several unique intracardiac pressure vents, placement catheters, methods of placement and methods of treating heart failure are presented. The intracardiac pressure vents presented allow sufficient flow from the left atrium to the right atrium to relieve elevated left atrial pressure and resulting patient symptoms but also limit the amount of flow from the right atrium to the left atrium to minimize the potential for thrombus or other embolic material from entering the arterial circulation.

Intra-atrial implants to directionally shunt blood

Growing community of inventors

Chemsford, MA, United States of America

Edward I McNamara