University of Massachusetts

University of Miami

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Edward I Ginns

Gary R Ostroff

Marzena Galdzicka

Janice A Egeland

Steven Marc Paul

Methods for treating and diagnosing psychiatric affective disorders, e.g., an affective disorder associated with aberrant Sonic Hedgehog (Shh) signaling, by administering to the subject a therapeutically effective amount of an antagonist to Smoothened (Smo), an antagonist to Patched-1 (Ptch-1) and/or an antagonist to Shh.

Aberrant sonic hedgehog signaling in neuropsychiatric disorders

The present invention provides a therapeutic delivery system comprising an extracted yeast cell wall comprising beta-glucan, a payload trapping molecule and a payload molecule, wherein the payload molecule and the payload trapping molecule are soluble in the same solvent system wherein the payload molecule supplements the function of the deficient lysosomal enzyme. The invention further provides methods of making and methods of using the therapeutic delivery system.

Therapy for lysosomal enzyme deficiencies

The invention relates to systems and methods for analyzing clinically relevant nucleic acid sequences.

Systems and methods for analyzing nucleic acid sequences

Chromosomal regions comprising loci associated with susceptibility and resistance to bipolar affective disorder have been identified. Methods and compositions are provided for determining the contribution of these chromosomal regions to bipolar affective disorder in an affected family, for determining in an affected family a genotype associated with increased or decreased susceptibility or resistance to bipolar illness, and for assessing an increased or decreased risk of developing bipolar illness for a tested individual from an affected family.

Growing community of inventors

Shrewsbury, MA, United States of America

Edward I Ginns