Ampac Fine Chemicals LLC

Discovery Laboratories, Inc.

Other

Cytrx Corporation

Windtree Therapeutics, Inc.

Lyophilization Technology, Inc.

Edward H Trappler

Michael S Thomas

Sergio Cesco-Cancian

Thomas Hoy

Andrew M Smith

Timothy S Dutill

Daniel Levitt

Carrie Nodgaard

Scott Geyer

Daniel J Levitt

A carrier for supporting containers such as syringes or cartridges in a lyophilization chamber during lyophilization of substances contained therein, comprises a base assembly with an array of holes for receiving the containers. Each hole includes a heat-conductive metal portion for engagement with lower parts of the container held therein and a relatively non-conductive polymeric portion surrounding a portion of the container above the lower portion for enhancing the vertical growth of relatively large ice crystals. An upper part of the carrier supported above the base assembly includes a plunger-holding plate for frictionally holding elastomeric plungers and a pusher plate movable toward the plunger-holding plate and having protrusions for pushing the plungers out of the plunger-holding plate and into the containers before the containers are removed from the chamber.

Apparatus for lyophilization of products contained in product delivery units

The invention relates to reconstituted formulations comprising an anthracycline compound, ethanol, and water. The invention also relates to injectable compositions comprising the reconstituted formulation and Lactated Ringer's solution. Additionally, the invention relates to methods of using the formulations and compositions.

Anthracycline formulations

An improved lyophilized cyclophosphamide solid composition is described. The lyophilized cyclophosphamide solid composition is thermally stable, contains anhydrous cyclophosphamide and mannitol, and is substantially free of cyclophosphamide monohydrate. A method for preparing the lyophilized cyclophosphamide solid composition is also provided.

Lyophilized cyclophosphamide composition and methods of preparation thereof

Lyophilized pulmonary surfactants having an increased specific surface area and porosity are described. Methods of making the lyophilized pulmonary surfactants are also described.

Lyophilization of synthetic liposomal pulmonary surfactant

Lyophilized pulmonary surfactants having an increased specific surface area and porosity are described. A method of making lyophilized pulmonary surfactants is described.

A vacuum-chamber, batch-process, freeze dryer system, of the type usable for pharmaceutical, diagnostic and chemical processing applications, incorporates extensive regulation of a carrier gas injected in minute quantities into an evacuated vacuum chamber and a distribution system which regulates a more even flow over each of a plurality of material holding containers held within the evacuated vacuum chamber of the carrier gas.

Growing community of inventors

Langhorne, PA, United States of America

Edward H Trappler