W. L. Gore & Associates, Inc.

Gore Enterprise Holdings, Inc.

Other

W. L. Gore & Assoc. Inc.

Wayne D. House

Edward H. Cully

Michael J. Vonesh

Daniel B. Pond

Jeffrey B. Duncan

Keith M. Flury

Vrad W. Levering

Paul D. Goodman

Jason M. Wiersdorf

Philip P. Off

Daniel M. O'shea

Edward H Cully

Michael J Vonesh

Jeffrey B Duncan

Joseph R Armstrong

Benjamin M Trapp

Edward Emil Shaw

Mark Y Hansen

Robert L Cleek

Mark Joseph Ulm

Keith M Flury

William D Montgomery

Wendy J Terry

James D Silverman

Carey V Campbell

Larry J Kovach

Nathan L Friedman

Paul D Drumheller

James L Goepfrich

Douglas S Paget

Cody L Hartman

Sherif A Eskaros

Eric M Tittelbaugh

Brandon A Lurie

Theresa A Holland

David M Williams

Thomas R McDaniel

Coby C Larsen

Matthew E Maulding

Woodrow W Watson

Peter Heicksen

Eric H Zacharias

Michael W Franklin

Craig R McMurray

Cody L Bliss

Wayne D House

Rachel Radspinner

Paul D Goodman

Michael C Nilson

Jeffrey J Kustusch

Craig T Nordhausen

Timothy T Stringer

Lauren Zambotti

Joseph B Koenig

Joel M Greene

Joshua J Lovekamp

Ryan D Kariniemi

Claudio Schonholz

William P Witort

Michelle L Gendron

Brian C Martonik

Zahid Amin

Warren Cutright

Charles J Flynn

Juan C Parodi

William C Bruchman

Steven J Masters

Bret J Kilgrow

John E Bacino

Dustin C Burkart

Deenu G Kanjickal

James William Mann

Stanislaw L Zukowski

Charles F White

Paul D Gassler

Greg Rusch

Mei Li

Michael D Dake

Bruce M Steinhaus

Edward C Gunzel

William G Hardie

Peter J Roeber

Craig W Irwin

George N Foutrakis

John Cheer

Jason M Wiersdorf

Keith Knisley

Eric A Mokelke

Aaron J Hopkinson

John M Squeri

Ted R Farnsworth

James Todd Walter

Michael R Broyles

Brandon C Short

Byron K Hayes

Marc A Schlaud

Scot K Mathena

Joseph A Huppenthal

Mark C Bates

Thomas G Triebes

Martin J Sector

Paul Christopher Begovac

Nathan K Mooney

Lawrence A Ford

Roark N Wolfe

Alexander Zaggl

Benjamin A Smith

Thane L Kranzler

Christopher John Vecchio

David J Messick

Implantable grafts, particularly for arteriovenous access that may be punctured by an object such as a needle and, following removal of the object, will reseal the resulting hole to the extent of reducing fluid leakage through the graft at the puncture site to an amount less than would be typical for a conventional graft. More particularly, the grafts comprise three layers; an inner layer of implantable graft material such as ePTFE, a middle layer of self sealing elastomeric material such as silicone, and an outer layer of implantable graft material such as ePTFE. Following manufacture, the tubular form of the three-layer graft is everted to put substantially the entire wall thickness of the elastomeric material layer under circumferential compression.

Puncturable and resealable graft

A therapeutic device includes a pouch having opposed first and second ends and first and second composite layers extending between the opposed first and second ends. The first composite layer includes a first cell permeable layer extending between the opposed first and second ends and a first cell retentive layer extending between the opposed first and second ends. The pouch includes a reservoir formed between the first and second composite layers, contacting the first cell retentive layer, and at least one port in fluid communication with the reservoir. The therapeutic device further includes a removal element configured to operably engage the first end of the pouch, to cause the first end to be moveable towards the second end by eversion. In some embodiments, each of the first and second composite layers includes a plurality of wrinkles that are incrementally disengaged from a tissue to remove the therapeutic device atraumatically.

Atraumatic removable cell encapsulation devices

The present disclosure is directed toward composite materials comprising high aspect ratio habits of drug crystals which can be partially or fully extending into a substrate, and additionally, can be projecting from a substrate at an angle of about 20° to about 90°. The present disclosure is directed toward medical devices, such as medical balloons, comprising said composite and methods of using and making the same. The described composite can be used for the local treatment of vascular disease. The present disclosure is also directed toward paclitaxel crystals with a hollow acicular habit.

Porous composites with high-aspect ratio crystals

The present disclosure comprises devices, systems, and methods having an inverted sheath configured to cover, and in some instances constrain, a medical device and to retract through eversion, thus enabling the deployment of medical device at the treatment site. A constraining sheath can evert hydraulically. A constraining sheath can be configured to neck down a medical device to achieve a lower delivery profile. Furthermore, a constraining sheath can comprise a balloon to expand or positionally or structurally adjust a medical device.

Evertable sheath devices, systems, and methods

The invention comprises an indwelling medical device which is capable of delivering a therapeutic agent evenly along the length of the indwelling portion, including the outer wall, of the device.

Indwelling luminal devices

Exemplary embodiments comprise AV fistulas and other anastomotic devices for creating new or reinforcing existing side-branch vessels, and/or bridging neighboring vessels together. An exemplary embodiment may comprise a sidewall port, such as a flanged sidewall port, and/or flow frame design, such as a partially bare, flexible stent or a whisk, for purposes of creating a transmural flow. Another exemplary embodiment may comprise a compliant vessel support to aid in the transition from device to vessel and/or vessel to device, and to promote vessel dilation.

Anastomotic devices and methods

A stent incorporating flexible, preferably polymeric, connecting elements into the stent wherein these elements connect adjacent, spaced-apart stent elements. Preferably the spaced-apart adjacent stent elements are the result of forming the stent from a helically wound serpentine wire having space provided between adjacent windings. Other stent forms such as multiple, individual spaced-apart ring-shaped or interconnected stent elements may also be used. The connecting elements are typically web-shaped and result from creating slits or apertures in a covering of graft material applied to the stent and then, for example, applying heat to cause the slits or apertures to enlarge. The remaining graft material forms the interconnecting webs between the adjacent stent elements.

Stent having adjacent elements connected by flexible webs

An endoluminal device comprises a tubular member and a reinforcement member that is separable from, or together with, a wall of the tubular member, and removable in-situ.

Deconstructable endoluminal devices and related systems and methods

An implantable containment apparatus for receiving and retaining a biological moiety, including a plurality of cells, for insertion into a patient, such as into a tissue bed, is disclosed. The device includes a cell encapsulating pouch that forms and interior volume having a reservoir space for receiving cells, where the reservoir space includes first and second interior surfaces, and a tensioning member to maintain an average distance between the first interior surface and the second interior surface.

Cell encapsulation devices with controlled cell bed thickness

A diametrically adjustable endoprosthesis includes a controlled expansion element extending along at least a portion of a graft and is supported by a stent. The controlled expansion element diametrically constrains and limits expansion of the endoprosthesis. Upon deployment from a smaller, delivery configuration, the endoprosthesis can expand to the initial diameter set by the controlled expansion element. Thereafter, the endoprosthesis can be further diametrically expanded (e.g., using balloon dilation) by mechanically altering the controlled expansion element.

Diametrically adjustable endoprostheses and associated systems and methods

The present disclosure relates to implantable encapsulation devices for housing a biological moiety or a therapeutic device that contains a biological moiety. Particularly, aspects of the present disclosure are directed to an implantable apparatus that includes a distal end, a proximal end, a manifold including at least one access port positioned either at the distal end or the proximal end, and a plurality of containment tubes affixed to the manifold and in fluid communication with the at least one access port. Additionally, the encapsulation device may contain a flush port and a tube that are fluidly connected to the manifold. The containment tubes may contain therein a biological moiety (e.g., cells) or a therapeutic device (e.g. a cell encapsulation member).

Implantable encapsulation devices

The invention relates to a medical device and a method of using it. The device is a stent which can be percutaneously deliverable with (or on) an endovascular catheter or via other surgical or other techniques and then expanded. The stent is configured to have a central portion defined by 'open' cells and at least two end portions, defined by “closed” cells, spaced apart and directly connected to the distal and proximal ends of the central portion of the stent. The stent may also optionally have a covering or a lattice with openings.

Stent

Embodiments of the present disclosure comprise occlusion and drug delivery devices and methods. One aspect of the disclosure comprises a drug delivery device comprising an inner expansion member and an outer drug delivery component. Another aspect of the disclosure comprises bioabsorbable, lumen-occluding implants.

Vascular occlusion and drug delivery devices, systems, and methods

The invention relates to medical devices and methods of using them. The devices are prostheses which can be percutaneously deliverable with (or on) an endovascular catheter or via other surgical or other techniques and then expanded. The prostheses are configured to have a lattice resistant to dilation and creep, which is defined by a plurality of openings. The prosthesis may also optionally have a stent disposed proximal to the lattice. In exemplary embodiments, the fluoropolymer is expanded polytetrafluoroethylene. The composite materials exhibit high elongation while substantially retaining the strength properties of the fluoropolymer membrane. In at least one embodiment, the lattice is made of a composite material that includes a least one fluoropolymer membrane including serpentine fibrils and an elastomer. A lattice including a generally tubular member formed of a composite material including a least one fluoropolymer membrane containing serpentine fibrils and an elastomer is also provided.

Lattice

An implantable containment apparatus for receiving and retaining a plurality of cells for insertion into a patient, such as into a tissue bed, is disclosed. The device includes a chamber having structural spacers therein to maintain an average distance between the first interior surface and the second interior surface of the chamber and to define at least one reservoir space for the placement of cells within the chamber.

Cell encapsulation devices containing structural spacers

Growing community of inventors

Flagstaff, AZ, United States of America

Edward H Cully