Merck + Co., Inc.

Merck Sharp + Dohme Corp.

Edward Gonzalez

William H Parsons

Prasun K Chakravarty

Hyun O Ok

Min K Park

Brenda L Palucki

Rosemary Sisco

Bishan Zhou

Louis L Zuegner, Iii, Legal Representative

Michael H Fisher

Brenda Palucki

Substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, migraine, headache pain, migraine headache, epilepsy, irritable bowel syndrome, diabetic neuropathy, multiple sclerosis, manic depression and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.

Substituted triazoles as sodium channel blockers

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Iselin, NJ, United States of America

Edward Gonzalez