Other

Edward Giovannucci

Michael N Pollak

Meir J Stampfer

Myles Edward Brown

Philip W Kantoff

Methods of predicting a propensity to developing prostate cancer are presented. The method consists of measuring the IGF status of individual. Individuals with high IGF status, as compared with normal reference range values, are at increased risk for developing prostate cancer. More particularly, the IGF status may be determined by measuring IGF-I levels and/or IGFBP-3 levels. High IGF and low IGFBP levels are indicative of a high IGF status. A method of determining the prognosis of existing prostate cancers or of monitoring disease progression involves determining the IGF/PSA status of an individual. Individuals with a high IGF/PSA status (both high IGF status and high PSA levels) tend to develop severe prostate cancer and have a poorer overall prognosis.

Circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3 and prostate cancer risk

Methods of predicting a propensity to developing prostate cancer are presented. The consists of measuring the IGF status of individual. Individuals with high IGF status, as compared with normal reference range values, are at increased risk for developing prostate cancer. More particularly, the IGF status may be determined by measuring IGF-I levels and/or IGFBP-3 levels. High IGF and low IGFBP levels are indicative of a high IGF status. A method of determining the prognosis of existing prostate cancers or of monitoring disease progression involves determining the IGF/PSA status of an individual. Individuals with a high IGF/PSA staus (both high IGF status and high PSA levels) tend to develop severe prostate cancer and have a porrer overall prognosis.

Circulating insulin-like growth factor-I and prostate cancer risk

There is described a method for prognosis of prostate cancer in a male comprising: (a) determining the length of the CAG trinucleotide repeat of exon 1 of the androgenic receptor gene and/or the length of the TA dinucleotide repeat of the 5 alpha reductase Type II gene or its complement obtained from DNA of the male and (b) correlating the length of the repeat with the aggressiveness and mortality risk of the cancer in the male.

Growing community of inventors

Wakefield, MA, United States of America

Edward Giovannucci