Pfizer Corporation

Pfizer Products Inc.

Edward F Kleinman

Robert L Rosati

Jasjit S Bindra

Ralph P Robinson

Victoria Lee Cohan

Robert A Volkmann

Donald K Pirie

Anthony Marfat

Michael Aaron Brodney

Brian Thomas O'Neill

Yuhpyng Liang Chen

Wayne E Barth

Kelvin Cooper

Allen Jacob Duplantier

Lawrence Alan Reiter

Robert James Chambers

Karen Jean Coffman

Hiroko Masamune

Yves Andre Chantigny

John B Cheng

Vinod Dipak Parikh

John W Watson

Yves A Chantigny

Jasit S Bindra

The present invention relates to compounds of Formula I wherein R, R, R, R, R, Rand A are as defined. Compounds of Formula I have activity inhibiting production of A&#x3b2;-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of Formula I.

Imidazole compounds for the treatment of neurological disorders

The present invention provides compounds of the formula  and X, Y, n, R&#x2014;Rare as described in the specification which are modulators of the glucocorticoid receptor and are thus useful for the treatment of animals requiring glucocorticoid receptor agonist therapy. Glucocorticoid receptor modulators are useful in the treatment of certain inflammatory conditions.

Modulators of the glucocorticoid receptor

The present invention provides compounds of the formula wherein A is of the formula and X, Y, n, R&#x2013;Rare as described in the specification which are modulators of the glucocorticoid receptor and are thus useful for the treatment of animals requiring glucocorticoid receptor agonist therapy. Glucocorticoid receptor modulators are useful in the treatment of certain inflammatory conditions.

5-arylsulfonyl-imidazo&lsqb;1&prime;,2&prime;:1,6&rsqb;pyrido&lsqb;2,3-b&rsqb;pyrazine-6-amines and related compounds

N-(aroyl)glycine hydroxamic acid derivatives and related compounds

A compound of formula (I) wherein m, n, o, p, q, r, A, B, D, E, R , R ,R , R , R , R , R and R are as defined in the description, useful in the treatment of respiratory, allergic, rheumatoid, body weight regulation, inflammatory and central nervous system disorders such as asthma, chronic obstructive pulmonary disease, adult respiratory diseases syndrome, shock, fibrosis, pulmonary hypersensitivity, allergic rhinitis, atopic dermatitis, psoriasis, weight control, rheumatoid arthritis, cachexia, crohn's disease, ulcerative colitis, arthritic conditions and other inflammatory diseases, depression, multi-infarct dementia and AIDS.

Nicotinamide derivatives

Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R,, R,, AA and Y are as defined herein, inhibit phosphodiesterase type IV or inhibit the production of tumor necrosis factor, and therefore are useful in the treatment of certain conditions and diseases including asthma, arthritis, and sepsis.

N-(aroyl) glycine hydroxamic acid derivatives and related compounds

1-aryl-3-arylmethyl-1,8-naphthyridin-4(1H)-ones

This invention relates to isoxazoline compounds which are inhibitors of tumor necrosis factor (TNF). The isoxazoline compounds are useful for inhibiting TNF in a mammal in need thereof and in the treatment or alleviation of inflammatory conditions or disease, including but not limited to rheumatoid arthritis, osteoarthritis, asthma, bronchitis, chronic obstructive airways disease, psoriasis, allergic rhinitis, dermatitis and inflammatory bowel disease, sepsis, septic shock, tuberculosis, graft versus host disease and cachexia associated with AIDS or cancer. This invention also relates to pharmaceutical compositions useful therefor comprising such compounds.

Isoxazoline compounds as inhibitors of TNF release

Antiviral thiazoles

Isoxazoline compounds as antiinflammatory agents

Isoxazoline compounds as 5-lipoxygenase inhibitors

3-aryl-2-isoxazolines as antiinflammatory agents

Antiinflammatory and analgesic oxindole prodrugs of the formula ##STR1## wherein R.sup.10, R.sup.11, R.sup.12 and R.sup.13 are hydrogen, alkyl or halogen and R is methyleneoxyalkanoyl, methyleneoxyalkenoyl or alkenoyl.

Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides

Growing community of inventors

Pawcatuck, CT, United States of America

Edward F Kleinman