G.d. Searle & Company

Monsanto Company

Ppg Industries, Inc.

Pharmacia Corporation

Pharmacia Corporation (of Pfizer, Inc.)

Edward E Yonan

John S Ng

Bernhard Erb

Ping T Wang

Yuen-Lung L Sing

Leo J Letendre

Joseph J Wieczorek

Mark John Pozzo

Chin Liu

Jon P Lawson

Sastry A Kunda

Dennis K Anderson

Julio A Baez

Fortunato Vanzanella

Gennaro Mucciariello

Richard M Weier

Thomas R Kowar

John Jeffrey Talley

John R Medich

Kathleen T McLaughlin

Henry T Gaud

Bryan H Landis

Ralph B Thompson

Ravindra S Topgi

Susan B Gorman

A stable crystalline form of 4-[5-methyl-3-phenylisoxazol-4-yl]benzenesulfonamide is described. This crystal structure, designated Form B, is more stable, has favorable handling properties and is characterized by its melting point, x-ray and other physical characterizations.

Crystalline form of 4-[5-methyl-3-phenylisoxazol-4-yl] benzenesulfonamide

Multiple novel keto-substituted intermediates are provided for the synthesis of epoxymexrenone, useful as an Aldosterone Receptor Antagonist.

Keto-substituted steroid compounds

Intermediates in the preparation of 9,11-epoxy steroids are disclosed. Particularly, disclosed are 11,12-epoxy steroid, 4,5-9,11-diepoxy steroid and 12-keto steroid intermediates.

Processes for preparation of 9,11-epoxy steroids and intermediates useful therein

Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula Iwherein:

Process for preparation of 9, 11-epoxy steroids and intermediates useful therein

Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula Iwherein: &#x2014;A&#x2014;A&#x2014;, &#x2014;B&#x2014;B&#x2014;, R, R, Rand Rare as defined in the specification.

Processes for the preparation of 4,5-dihydro-5,7-lactone steroid compounds are provided.

Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein

Process for preparation of 9,11-epoxy steroids and intermediates useful therein

A stable crystalline form of 4-&lsqb;5-methyl-3-phenylisoxazol-4-yl&rsqb;benzenesulfonamide is described. This crystal structure, designated Form B, is more stable, has favorable handling properties and is characterized by its melting point, x-ray and other physical characterizations.

Crystalline form of 4-&lsqb;5-methyl-3-phenylisoxazol-4-yl&rsqb; benzenesulfonamide

5&bgr;-cyano-substituted steroid compounds

A process for the formation of an epoxy compound comprising contacting a substrate compound having an olefinic double bond with a peroxide compound in the presence of a peroxide activator, said peroxide activator corresponding to the formula:

Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone, useful as a diuretic, and other compounds of Formula I

Keto-Substituted Steroid Compounds

A method for preparing a chiral beta amino acid or its corresponding esters which comprises contacting a racemic beta amino acid, an acyl donor and Penicillin G acylase enzyme under conditions appropriate to stereoselectively acylate one enantiomer of the racemic beta amino acid to its corresponding N-acylated derivative whereby the opposite enantiomer of the beta amino acid is retained in enantiomerically enriched form.

Method and apparatus for preparation of chiral beta amino acids using penicilln G acylase

Multiple reaction schemes, process steps and intermediates are provided for the synthesis of epoxymexrenone, useful as a diuretic, and other compounds of Formula I

Growing community of inventors

Carol Stream, IL, United States of America

Edward E Yonan