Gilead Sciences, Inc.

Edward Doerffler

Michael O'Neil Hanrahan Clarke

Dustin S Siegel

Richard L Mackman

Choung U Kim

William John Watkins

Aesop Cho

Adrian S Ray

Hon Chung Hui

Jay P Parrish

Lee Shun Chong

Robert Jordan

Jianying Wang

Scott E Lazerwith

Eda Y Canales

Willard Lew

Xiaoning C Sheng

Maria Fardis

Qi Liu

Philip Anthony Morganelli

Michael O Clarke

Michael O' Neil Hanrahan Clarke

Manoj C Desai

Zheng-Yu Yang

Jennifer R Zhang

William A Lee

John C Rohloff

Gary Paul Cook

Gong-Xin He

Andrew C Stevens

Tiago Vieira

Hyung-Jung Pyun

Byoung-Kwon Chun

Xianghong Wang

Robert William Scott

Qiaoyin Wu

Mingzhe Ji

Bruce Ross

Zhenhong R Cai

Lars V Heumann

Katrien Brak

Andrew W Waltman

Silvio A Campagna

Byoung Kwon Chun

Michael Mertzman

Anthony Casarez

Kleem Chaudhary

Hyungjung Pyun

Dustin Siegel

Xiaoqin Cheng

Michael O'neil Hanrahan Clarke

Robert Ronald Milburn

Sean Timothy Neville

Pavel Robertovich Badalov

Andrei Chtchemelinine

Morin Mae Frick

Detian Gao

Mark Charles Whitcomb

Silvio Campagna

Erik Rueden

Clarissa Tadeus

Steven Donald Axt

Lydia Wolfe

Chia-Yun Yu

Brittanie Hoang

Hong Ye

Michael O'neil Clarke

Gary P Cook

Erick Rueden

Tiago Viera

Xiaqin Cheng

The present disclosure provides a compound of Formula I:

Antiviral compounds

Provided are methods of preparing compounds and pharmaceutical compositions comprising a compound Formula VIII for treating Filoviridae virus infections. In one aspect, the compound of Formula VIII is formed from a reaction mixture comprising the compound of Formula IX, the compound of Formula X, a coupling agent such as magnesium chloride and a non-nucleophilic base such as diisopropylethylamine. The compound of Formula IX can be formed from a compound of Formula V and a cyanating agent. The compound of Formula V can be synthesized from a reaction mixture comprising a deprotonating agent such as phenylmagnesium chloride; a silylating agent such as chlorotrimethylsilane; a coupling agent such as isopropylmagnesium chloride, an additive such as LaCl-2LiCl, LaCl, CeCl, NdCl, or YCl; a compound of Formula VI; and 7-iodopyrrolo[2,1-f][1,2,4]triazin-4-amine. The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

Methods for the preparation of ribosides

Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

Methods for treatingvirus infections

Methods for treating filoviridae virus infections

Provided herein are formulations, methods and substituted tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds. 

Pyrrolo[1,2-f][1,2,4]triazines useful for treating respiratory syncitial virus infections

Methods for treating Filoviridae virus infections

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The present application includes novel inhibitors of HCV, compositions containing such compounds, therapeutic methods that include the administration of such compounds.

Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

Inhibitors of flaviviridae viruses

Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections (e.g. hepatitis C infections), particularly drug resistant Flaviviridae virus infections.

Growing community of inventors

Union City, CA, United States of America

Edward Doerffler