Bend Research, Inc.

Ignyta, Inc.

Ben Research, Inc.

Edward Dennis LaChapelle

Dwayne Thomas Friesen

Leah Elizabeth Appel

Sanjay Konagurthu

Joshua R Shockey

Walter Christian Babcock

Scott B McCray

Robert L Orr

Richard Frank Falk

Joseph P Reo

Matthew Jarud Shaffer

Charlie Michael McLaughlin

Kathryn Emily Colombo Pugh

Kris A Krichko

Brent Antone Uhrig

Joshua Richard Shockey

A pharmaceutical composition comprises multiparticulates comprising a melt-congeal core and a solid amorphous dispersion layer of a poorly water soluble drug and polymer. The multiparticulates are suitable for improving bioavailability of poorly water soluble drugs. The melt-congeal cores facilitate application of the solid amorphous dispersion layer, and allow incorporation of additional optional components to the core so as to adjust the release of drug from the multiparticulate.

Multiparticulates of spray-coated drug and polymer on a meltable core

The present disclosure relates to pharmaceutical compositions comprising N-[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)-benzamide and a polymer, dosage forms comprising the formulation and methods of treating subjects having cancer.

Pharmaceutical compositions and dosage forms

A pharmaceutical composition comprises multiparticulates comprising a drug, a matrix material, and swelling agent. In one aspect, the multiparticulates comprise a core comprising a drug, and a coating surrounding the core. The coating is selected from the group consisting of (i) a water-permeable, substantially drug-impermeable coating, and (ii) an anti-enteric coating.

Taste-masked drugs in rupturing multiparticulates

A process for improving both the internal burst strengths and gas and water permeabilities of certain microporous polymeric hollow fibers useful in RO applications comprises a wet annealing process for certain such fibers.

Hollow fiber annealing

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Bend, OR, United States of America

Edward Dennis LaChapelle