Protiva Biotherapeutics, Inc.

Arbutus Biopharma Corporation

Edward D Yaworski

Ian MacLachlan

Lorne Ralph Palmer

Lloyd B Jeffs

Kieu Lam

Michael J Abrams

James Heyes

Adam Judge

Mark Wood

Stephen P Reid

Kieu Mong Lam

Ian Maclachlan

Alan D Martin

The present invention provides compositions comprising nucleic acid molecules, such as mRNA molecules, encapsulated within lipid particles. The compositions are useful, for example, to introduce the mRNA molecules into a human subject where they are translated to produce a polypeptide that functions to ameliorate one or more symptoms of a disease.

Compositions and methods for delivering messenger RNA

The present invention provides novel, stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles. More particularly, the present invention provides stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (such as one or more interfering RNA), methods of making the SNALP, and methods of delivering and/or administering the SNALP.

Lipid formulations for nucleic acid delivery

The present invention provides apparatus and processes for producing liposomes. By providing a buffer solution in a first reservoir, and a lipid solution in a second reservoir, continuously diluting the lipid solution with the buffer solution in a mixing chamber produces a liposome. A therapeutic agent, such as nucleic acid, is included in one of the buffer solution or the lipid solution. Upon mixing a liposome encapsulating the therapeutic product is substantially instantaneously formed. Thereafter the liposome solution formed is immediately diluted with buffer solution to enhance homogeneity and maintain small particle size.

Systems and methods for manufacturing liposomes

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Maple Ridge, Canada

Edward D Yaworski