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Pfizer Corporation

Oxford University Innovation Ltd

Rising Tide Foundation

Edward Cochrane

Brett Stevenson

Andrew Ratcliffe

Tim Sparey

David James Hallett

Alexandre Froidbise

George Stuart Cockerill

James Good

Franz Lagasse

Gilbert Lassalle

Craig Alex Avery

Andrew Joseph Warner

David Hallett

Benzodiazepine derivatives of formula (I): (I) wherein: each of Rand Ris independently H or halo; either (i) T is N, Z is C,andare bonds, andandare absent; or (ii) T is C, Z is N,andare bonds, andandare absent; each of Rand Ris independently halo, —OR, —NRR, —COR, —C(O)OR, —CON(R)or —R; Ris H or halo; each of Rand Ris independently H or a group selected from C-Calkyl, C-Ccycloalkyl, C-Caryl, 4- to 10-membered heterocyclyl and 4- to 10-membered heteroaryl, the group being unsubstituted or substituted; Ris H or C-Calkyl, each Rbeing the same or different when two are present; n is 0 or 1; and one of V, W, X and Y is N or CH and the other three are CH; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.

Pharmaceutical compounds

Benzodiazepine derivatives of formula (I): (I) wherein: each of Rand Ris independently H or halo; either (i) T is N, Z is C, -a- and -c- are bonds, and -b- and -d- are absent; or (ii) T is C, Z is N, -b- and -d- are bonds, and -a- and -c- are absent; each of Rand Ris independently halo, &#x2014;OR, &#x2014;NRR&#x2014;COR, &#x2014;C(O)OR, &#x2014;CON(R)or &#x2014;R; Ris H or halo; each of Rand Ris independently H or a group selected from C-Calkyl, C-Ccycloalkyl, C6-C10 aryl, 4- to 10-membered heterocyclyl and 4- to 10-membered heteroaryl, the group being unsubstituted or substituted; Ris H or C-Calkyl, each Rbeing the same or different when two are present; n is 0 or 1; and one of V, W, X and Y is N or CH and the other three are CH; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.

This invention relates to compounds that are useful as cancer therapies. The compounds comprise azithromycin derivatives having a phosphonium cation tethered to the azithromycin macrocycle. The invention also relates to methods of using said compounds and to pharmaceutical formulations comprising said compounds.

Azithromycin derivatives containing a phosphonium ion as anticancer agents

This invention relates to compounds that are useful as cancer therapies. The compounds comprise azithromycin derivatives having a phosphonium cation tethered to the azithromycin macrocycle. The invention also relates to methods of using said compounds and the pharmaceutical formulations comprising said compounds.

This invention relates to compounds that are useful as cancer therapies. The compounds comprise derivatives of tetracycline antibiotics, e.g. doxycycline, having a phosphonium cation tethered to the tetracycline tetracycle. The invention also relates to methods of using said compounds and to pharmaceutical formulations comprising said compounds.

Phosphonium-ion tethered tetracycline drugs for treatment of cancer

Triphenylphosphonium-tethered tetracyclines for use in treating cancer

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Nottingham, United Kingdom

Edward Cochrane