Aesgen, Inc.

Eisai Inc.

Aesqen, Inc.

Aesgan, Inc.

University of Arkansas

Edward C Shinal

Robert G Petit, Ii

V Suzanne Klimberg

Robert G Ii Petit

Provided are methods of treating cancer, and/or the side effects of cancer therapy, involving the administration of glutamine, optionally in combination with a carbohydrate carrier that enhances the absorption of glutamine.

Treatment of cancer with glutamine

Provided is a composition and a method for increasing cellular uptake of bioactive agents, particularly those compounds termed 'small molecules' into the cells of mammalian tissue, such as the epithelial cells of the mucosa.

Cellular uptake of bioactive agents

The invention provides a method of preparing anhydrous disodium pamidronate or an aqueous disodium pamidronate solution for pharmaceutical use.

Method for preparation of disodium pamidronate

Provided is a composition and a method for increasing cellular uptake of bioactive agents, particularly those compounds termed &ldquo;small molecules&rdquo; into the cells of mammalian tissue, such as the epithelial cells of the mucosa.

The invention provides amorphous disodium pamidronate having no more than about 1-2 wt-% water.

The invention provides a therapeutic calcitriol solution which is suitable for packaging into pharmaceutical vials without producing discoloration of the antioxidant component of the solution.

Stable calcitriol solution for packaging into vials

The invention includes a method for the preparation of disodium pamidronate comprising: (a) preparing a stirred slurry of pamidronate in water, (b) adding a solution of sodium hydroxide to give a clear solution at pH of about 6.5, (c) filtering the solution and (d) freezing and lyophilizing the solution to give an amorphous essentially anhydrous disodium pamidronate which contains .ltoreq.2 wt-% water.

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Pennington, NJ, United States of America

Edward C Shinal