W. L. Gore & Associates, Inc.

Other

Gore Enterprise Holdings, Inc.

Edward C Gunzel

Matthew A Johnson

Edgar G Ashmead

Michael Moritz

Michael P Moritz

Edward H Cully

Greg Rusch

Gregory D Culler

Lauren Zambotti

Keith Knisley

William D Kelsey

John Holcombe

Emmanuel Gustav Van-Dyck

John E Bacino

Brian Farnworth

Dattatreya Panse

William Shamrock

Bret Alan Snyder

Basak Irem Nase

Christine M Scotti

Dattatreya R Panse

Todd B Olson

John Holocombe

The present disclosure relates to implantable encapsulation devices for housing a biological moiety or a therapeutic device that contains a biological moiety. Particularly, aspects of the present disclosure are directed to an implantable apparatus that includes a distal end, a proximal end, a manifold including at least one access port positioned either at the distal end or the proximal end, and a plurality of containment tubes affixed to the manifold and in fluid communication with the at least one access port. Additionally, the encapsulation device may contain a flush port and a tube that are fluidly connected to the manifold. The containment tubes may contain therein a biological moiety (e.g., cells) or a therapeutic device (e.g. a cell encapsulation member).

Implantable encapsulation devices

A container having a barrier layer is provided. The container may be of thermoplastic and the barrier may inhibit materials from leaching from the thermoplastic material or from extraction of compounds from medicants by the thermoplastic. A process is also described that allows for molding thin barrier layers as container lines and for forming thermoplastic containers with barrier liners.

Fluoropolymer barrier material for containers

Non-fluoropolymer tie layer and fluoropolymer barrier layer

A storage bag configured to contain or that contains at least one therapeutic compound such as a viral vector and non-viral vector is provided. In one embodiment, the storage bag contains a viral vector and/or a non-viral vector containing genetic material. The storage bag has two edges and two ends including a first face and a second face integrally joined at the two edges of the bag and defining an inner surface and an outer surface forming the bag; the inner surface including a higher melting polymer, and the outer surface including a lower melting polymer; a joint at one of the ends; a discrete composite sheet having a first side including a higher melting polymer and a second side including a lower melting polymer folded over the joint with the first side including a lower melting polymer engaging the joint to form a lap seam over the joint.

Storage bag for containing therapeutic compounds

A pre-filled syringe having containing therein at least one therapeutic is provided. The syringe contains a silicone free barrel and an elastomeric syringe stopper that is covered with an expanded polytetrafluoroethylene barrier layer. The presence of a barrier layer that is at least partially porous on the outside of the syringe stopper improves the seal between the stopper and syringe barrel and minimizes the sliding force. In some embodiments, the barrel is formed of a glass material such as a borosilicate glass, that is free of silicone or other lubricants.

Silicone free drug delivery devices

Fluoropolymer barrier materials for containers

Laminates suitable for constructing waterproof and breathable articles such as protective clothing which are both comfortable and exhibit enhanced resistance to fire are described. Particularly, flame resistant laminate constructions are described comprising a meltable textile as the outermost layer laminated to an intermediate protective layer comprising a waterproof film laminated to an innermost fabric layer comprising a thermally stable textile. Laminate constructions of the present invention exhibit breathability on the order of at least 1000 MVTR, a water entry pressure of at least 0.5 psi and have a horizontal flame break open time of at least 10 seconds.

Fire resistant laminates and articles made therefrom

A selectively reflective construct, and a method for making the construct, are described. In one embodiment reflectance, transmission and absorption properties may be controlled in multiple electromagnetic bands. A construct is described comprising a) a thermally transparent, visually opaque substrate comprising a polymeric material and a colorant, and b) a thermally reflective layer comprising a low emissivity component which is optionally transparent to radar signal.

Multi-spectral, selectively reflective construct

Laminates are described having a durable outer film surface for use in making lightweight liquidproof articles of apparel, such as outerwear garments. A method of making the laminate and a lightweight outerwear garment having an abrasion resistant exterior film surface is described.

Lightweight, durable apparel and laminates for making the same

Laminates are described having a durable outer film surface for use in making lightweight liquidproof articles, including articles of apparel, such as outerwear garments. A method of making the laminate and a lightweight outerwear garment having an abrasion resistant exterior film surface is described.

Growing community of inventors

Oxford, PA, United States of America

Edward C Gunzel