Abbott Laboratories Corporation

Other

Edward B Touma

Murali Gopalakrishnan

James P Sullivan

Clark A Briggs

Jean-Marc Roch

Lisa M Monteggia

David G Mc Kenna

Kevin J Lynch

David G McKenna

Edward C Burgard

Tim Van Biesen

Wende Niforatos

Randy E Metzger

A variant human &#x3b1;7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &#x3b1;7 nAChR. Nucleic acid molecules encoding the variant human &#x3b1;7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.

Variant human &#x3b1;7 acetylcholine receptor subunit, and methods of production and use thereof

A variant human &agr;7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &agr;7 nAChR. Nucleic acid molecules encoding the variant human &agr;7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.

Variant human &agr;7 acetylcholine receptor subunit, and methods of production and use thereof

A variant human &agr;7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &agr;7 nAChR. Nucleic acid molecules encoding the variant human &agr;7 nAChR, receptors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.

Variant human &agr;7 acetylcholine receptor subunit, and methods of production and uses thereof

Human P2X,and P2X,purinergic receptor polypeptides are provided. Nucleic acid molecules encoding the aforementioned human P2X receptor polypeptide, and vectors and host cells containing such nucleic acid molecules, are also provided. In addition, methods are provided for producing these P2X receptor polypeptide, as are methods of using such polypeptides and host cells that express the same to screen for compounds having activity on P2X,and P2X,receptors. Further, therapeutic uses involving aspects of these receptors are contemplated.

Nucleic acids encoding a functional human purinoreceptor P2X2 and P2X4, and methods of production and use thereof

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Chicago, IL, United States of America

Edward B Touma